Involvement of Interleukin-10 in Analgesia of Electroacupuncture on Incision Pain
المؤلفون المشاركون
Dai, Wen-jing
Sun, Jia-lu
Li, Chao
Mao, Wei
Huang, Yun-ke
Zhao, Zhi-qi
Zhang, Yu-qiu
Lü, Ning
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Postincision pain often occurs after surgery and is an emergency to be treated in clinic.
Electroacupuncture (EA) is a Chinese traditional treatment widely used to cure acute or chronic pain, but its mechanism is not clear.
Interleukin-10 (IL-10) is a powerful anti-inflammatory cytokine that shows neuroprotective effects in inflammation and injury in the CNS.
The present study attempts to reveal that IL-10 is crucial for EA analgesia on postincision pain.
Methods.
A model of incision pain was established in C57BL/6J mice.
The pain threshold was detected by behavioral test, and the expression of IL-10 and its receptor was detected by an immunohistochemical method.
C-fiber-evoked field potentials were recorded by in vivo analysis.
Results.
The mechanical allodynia induced by paw incision was significantly inhibited by pretreatment of EA in mice.
Intrathecal injection of IL-10 neutralizing antibody (2 µg/10 µL) but not intraplantar injection (10 µg/10 µL) reversed the analgesia of EA.
The upregulations of IL-10 mRNA and protein were induced by EA at 6 h and 1 d after incision, respectively.
Spinal long-term potentiation (LTP), a substrate for central sensitization, was also suppressed by EA with IL-10.
IL-10 recombinant protein (1 µg/10 µL, i.t.) mimicked the analgesia of EA on mechanical allodynia and inhibition on the spinal LTP.
Posttreatment of EA after incision also transitorily relieved the mechanical allodynia, which can be blocked by spinal IL-10 antibody.
IL-10 and its receptor, IL-10RA, are predominantly expressed in the superficial spinal astrocytes.
Conclusions.
These results suggested that pretreatment of EA effectively prevented postincision pain and IL-10 in spinal astrocytes was critical for the analgesia of EA and central sensitization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dai, Wen-jing& Sun, Jia-lu& Li, Chao& Mao, Wei& Huang, Yun-ke& Zhao, Zhi-qi…[et al.]. 2019. Involvement of Interleukin-10 in Analgesia of Electroacupuncture on Incision Pain. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Wen-jing…[et al.]. Involvement of Interleukin-10 in Analgesia of Electroacupuncture on Incision Pain. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1151262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dai, Wen-jing& Sun, Jia-lu& Li, Chao& Mao, Wei& Huang, Yun-ke& Zhao, Zhi-qi…[et al.]. Involvement of Interleukin-10 in Analgesia of Electroacupuncture on Incision Pain. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر