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Chinese Herbal Medicine Formula Shenling Baizhu San Ameliorates High-Fat Diet-Induced NAFLD in Rats by Modulating Hepatic MicroRNA Expression Profiles
المؤلفون المشاركون
Yang, Qin-He
Zhang, Yu-Pei
Pan, Maoxing
Deng, Yuanjun
Zheng, Chuiyang
Nie, Huan
Tang, Kairui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objective.
The purpose of present study was to investigate the potential mechanism underlying the protective effect of Shenling Baizhu San (SLBZS) on nonalcoholic fatty liver disease (NAFLD) by microRNA (miRNA) sequencing.
Methods.
Thirty male Wistar rats were randomly divided into a normal control (NC) group, a high-fat diet (HFD) group, and an SLBZS group.
After 12 weeks, the biochemical parameters and liver histologies of the rats were assessed.
The Illumina HiSeq 2500 sequencing platform was used to analyse the hepatic miRNA expression profiles.
Representative differentially expressed miRNAs were further validated by qRT-PCR.
The functions of the differentially expressed miRNAs were analysed by bioinformatics.
Results.
Our results identified 102 miRNAs that were differentially expressed in the HFD group compared with the NC group.
Among those differentially expressed miRNAs, the expression levels of 28 miRNAs were reversed by SLBZS administration, suggesting the modulation effect of SLBZS on hepatic miRNA expression profiles.
The qRT-PCR results confirmed that the expression levels of miR-155-5p, miR-146b-5p, miR-132-3p, and miR-34a-5p were consistent with those detected by sequencing.
Bioinformatics analyses indicated that the target genes of the differentially expressed miRNAs reversed by SLBZS were mainly related to metabolic pathways.
Conclusion.
This study provides novel insights into the mechanism of SLBZS in protecting against NAFLD; this mechanism may be partly related to the modulation of hepatic miRNA expression and their target pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Maoxing& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Tang, Kairui& Zhang, Yu-Pei…[et al.]. 2019. Chinese Herbal Medicine Formula Shenling Baizhu San Ameliorates High-Fat Diet-Induced NAFLD in Rats by Modulating Hepatic MicroRNA Expression Profiles. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1151299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Maoxing…[et al.]. Chinese Herbal Medicine Formula Shenling Baizhu San Ameliorates High-Fat Diet-Induced NAFLD in Rats by Modulating Hepatic MicroRNA Expression Profiles. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1151299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Maoxing& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Tang, Kairui& Zhang, Yu-Pei…[et al.]. Chinese Herbal Medicine Formula Shenling Baizhu San Ameliorates High-Fat Diet-Induced NAFLD in Rats by Modulating Hepatic MicroRNA Expression Profiles. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1151299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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