![](/images/graphics-bg.png)
Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin α6β1 in the NOA Rats
المؤلفون المشاركون
Zhu, Zhiguo
Luo, Lianmin
Wang, Jiamin
Liu, Yangzhou
Zhao, Zhigang
Zhao, Shankun
Li, Ermao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the therapeutic effect of Shengjing capsules on nonobstructive azoospermia (NOA) in the rat model.
Methods.
Twenty-five male Sprague–Dawley rats were randomly divided into five groups as follows (n=5 per group): normal group, NOA group, and three Shengjing capsule treatment groups (low-dose, medium-dose, and high-dose groups, respectively).
HE staining and semen smear were performed to assess sperm quality.
The expression levels of PI3K/AKT and integrin α6/β1 were measured by qRT-PCR and western blot analyses.
Results.
In the NOA group, almost all of the seminiferous tubules were vacuolated with a thin layer of basal compartment containing some spermatogonial stem cells.
The counts of sperms in the NOA group were strongly lower than those of the normal group (P=0.0001).
The expression of PI3K/AKT and integrin α6/β1 was scarcely expressed in the NOA group.
All indexes mentioned above were significantly different from those of the medium- and high-dose groups (P=0.001, all).
The sperm count of rats treated with Shengjing capsules was significantly higher than that of the NOA group (P=0.0001).
The rats of Shengjing capsule groups had more layers of spermatogonial stem cells and spermatocytes, and some had intracavitary sperms.
Conclusions.
Shengjing capsules may be a promising therapeutic medicine for NOA.
The underlying mechanisms might involve activating SSCs by upregulating the integrin α6/β1 expression via the PI3K/AKT pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jiamin& Zhao, Shankun& Luo, Lianmin& Liu, Yangzhou& Li, Ermao& Zhu, Zhiguo…[et al.]. 2019. Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin α6β1 in the NOA Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jiamin…[et al.]. Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin α6β1 in the NOA Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1151316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jiamin& Zhao, Shankun& Luo, Lianmin& Liu, Yangzhou& Li, Ermao& Zhu, Zhiguo…[et al.]. Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin α6β1 in the NOA Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)