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Efficacy of Brazilian Propolis Supplementation for Japanese Lactating Women for Atopic Sensitization and Nonspecific Symptoms in Their Offspring: A Randomized, Double-Blind, Placebo-Controlled Trial
المؤلفون المشاركون
Igarashi, Gen
Segawa, Takaaki
Akiyama, Naoe
Nishino, Tamon
Ito, Takeru
Tachimoto, Hiroshi
Urashima, Mitsuyoshi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Propolis is a natural product collected from several plants by honeybees and mixed with beeswax and salivary enzymes.
In animal models, propolis suppressed IgE-mediated allergies.
However, there is no clinical evidence that propolis prevents human atopic sensitization, to the best of our knowledge.
Therefore, a randomized, double-blind, placebo-controlled trial was conducted to assess whether propolis supplementation for lactating women increases or decreases the level of total IgE and antigen-specific IgE in the serum of their offspring (i.e., atopic sensitization) at the time of their first birthday.
In addition, whether propolis supplementation improves or worsens nonspecific symptoms (e.g., eczema) in the lactating women and their offspring was also investigated.
This trial is registered with UMIN000020794.
Eligible pairs of mothers and their offspring (n=80) were randomized to two groups: propolis (n=40) and placebo (n=40).
Participants were evaluated every month, and 31 (78%) of the propolis group and 23 (58%) of the placebo group underwent blood tests at the first birthday of the offspring.
Total IgE ≥ 10 UA/ml was seen in 26 (84%) infants whose mothers were given propolis, which was not significantly different from the 19 (86%) given placebo (P=0.80).
Total IgE as a continuous variable was not significantly different between the propolis and placebo groups (P=0.70).
Antigen-specific IgE levels for mites, egg white, cow’s milk, and wheat, as both dichotomous and continuous variables, were not significantly different between the two groups.
Both in mothers and their offspring, there were no significant differences in the subjective improvements of nonspecific symptoms between the two groups.
Except for one mother who had transient and mild nausea, none of the other mothers or their offspring developed severe adverse events during the follow-up period.
In conclusion, compared with placebo, Brazilian propolis supplementation did not influence the risk of atopic sensitization in infants and neither did it improve nor worsen nonspecific symptoms in either mothers or their infants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Igarashi, Gen& Segawa, Takaaki& Akiyama, Naoe& Nishino, Tamon& Ito, Takeru& Tachimoto, Hiroshi…[et al.]. 2019. Efficacy of Brazilian Propolis Supplementation for Japanese Lactating Women for Atopic Sensitization and Nonspecific Symptoms in Their Offspring: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Igarashi, Gen…[et al.]. Efficacy of Brazilian Propolis Supplementation for Japanese Lactating Women for Atopic Sensitization and Nonspecific Symptoms in Their Offspring: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Igarashi, Gen& Segawa, Takaaki& Akiyama, Naoe& Nishino, Tamon& Ito, Takeru& Tachimoto, Hiroshi…[et al.]. Efficacy of Brazilian Propolis Supplementation for Japanese Lactating Women for Atopic Sensitization and Nonspecific Symptoms in Their Offspring: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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