A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease
المؤلفون المشاركون
Ma, Min
Duan, Lihong
Wu, Zhengzhi
Zeng, Qiang
Li, Longfei
Jin, Yu
Chen, Zongzheng
Cao, Meiqun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the potential active compounds and underlying mechanisms of Paeonia lactiflora Pall.
(PLP) on the treatment of Alzheimer’s disease (AD) based on network pharmacology.
Methods.
The active components of PLP were collected from Traditional Chinese Medicine System Pharmacology (TCMSP) database, and their possible target proteins were predicted using TCMSP, SwissTargetPrediction, and STITCH databases.
The putative AD-related target proteins were identified from Therapeutic Target Database (TTD), GeneCards, and MalaCards database.
The compound-target-disease network interactions were established to obtain the key targets about PLP acting on AD by network topology analysis.
Then, the function annotation and signaling pathways of key targets were performed by GO and KEGG enrichment analysis using DAVID tools.
Finally, the binding capacity between active ingredients and key targets was validated by molecular docking using SystemsDock tools.
Results.
There were 7 active compounds involving in 151 predicted targets identified in PLP.
Besides, a total of 160 AD-related targets were identified.
Among these targets, 30 shared targets of PLP and AD were acquired.
After topological analysis of the PLP potential target-AD target network, 33 key targets that were highly responsible for the therapeutic effects of PLP on AD were obtained.
Further GO and KEGG enrichment analysis showed that these key targets were significantly involved in multiple biological processes and pathways which participated in cell apoptosis and inflammatory response and maintained the function of neurons to accomplish the anti-AD activity.
The molecular docking analysis verified that the 7 active compounds had definite affinity with the key targets.
Conclusions.
The ameliorative effects of PLP on AD were predicted to be associated with regulating neural cell apoptosis, inflammatory response, and neurotrophy via various pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, and neurotrophin signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Qiang& Li, Longfei& Jin, Yu& Chen, Zongzheng& Duan, Lihong& Cao, Meiqun…[et al.]. 2019. A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1151412
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Qiang…[et al.]. A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1151412
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Qiang& Li, Longfei& Jin, Yu& Chen, Zongzheng& Duan, Lihong& Cao, Meiqun…[et al.]. A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1151412
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151412
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر