Randomized, Double-Blinded, Multicenter, Placebo-Controlled Trial of Shenfu Injection for Treatment of Patients with Chronic Heart Failure during the Acute Phase of Symptom Aggravation (Yang and Qi Deficiency Syndrome)
المؤلفون المشاركون
Xu, Hao
Mao, Jing-Yuan
Wang, Xiaolong
Zhang, Junhua
Du, Tinghai
Liu, Chunxiang
Wang, Xian-Liang
Zhao, Zhiqiang
Chen, Yuanping
Liu, Nan
Wu, Jianguang
Li, Rong
Xu, Yong
Wang, Lei
He, Jingsong
Zhai, Jingbo
Zhao, Guoyuan
Hou, Yazhu
Wang, Shuai
Yingqiang, Zhao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Shenfu injection (SFI) has shown a remarkable therapeutic effect in patients with chronic heart failure (CHF) during the acute phase of symptom aggravation since it became commercially available in 1987.
However, the therapeutic effect of SFI has not been validated in a standard clinical study.
As a pilot clinical trial, this study aimed to evaluate the safety and efficacy of SFI for treatment of CHF patients during the acute phase.
Methods.
A total of 160 patients experiencing acute phase CHF were enrolled in this study and randomly assigned to receive the placebo (placebo group, 150 ml glucose (GS)) or SFI (SFI group, 50 ml SFI + 100 ml GS) in addition to their standard medications for CHF treatment.
The treatment lasted for 7 ± 1 days, and the follow-up continued for 28 ± 3 days after treatment.
The primary endpoints were New York Heart Association (NYHA) classification and Traditional Chinese Medicine (TCM) syndrome scores.
Results.
After 7±1 days of treatment, the efficacy of SFI according to improvements in NYHA and TCM syndrome scores in the SFI group (78.38% and 89.19%, respectively) was significantly higher than that in the placebo group (61.43% and 60.00%, respectively; P<0.05).
The SFI group had a longer increase in amplitude than the placebo group (113.00 m versus 82.99 m, P<0.05).
The incidence of adverse events and other safety indices showed no significant differences between the two groups.
Conclusion.
SFI combined with conventional therapy for treatment of CHF during acute symptom aggravation ameliorated the cardiac dysfunction and clinical symptoms and improved the patients’ quality of life without any significant AEs compared with the conventional therapy alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xian-Liang& Zhao, Zhiqiang& Mao, Jing-Yuan& Du, Tinghai& Chen, Yuanping& Xu, Hao…[et al.]. 2019. Randomized, Double-Blinded, Multicenter, Placebo-Controlled Trial of Shenfu Injection for Treatment of Patients with Chronic Heart Failure during the Acute Phase of Symptom Aggravation (Yang and Qi Deficiency Syndrome). Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151652
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xian-Liang…[et al.]. Randomized, Double-Blinded, Multicenter, Placebo-Controlled Trial of Shenfu Injection for Treatment of Patients with Chronic Heart Failure during the Acute Phase of Symptom Aggravation (Yang and Qi Deficiency Syndrome). Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151652
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xian-Liang& Zhao, Zhiqiang& Mao, Jing-Yuan& Du, Tinghai& Chen, Yuanping& Xu, Hao…[et al.]. Randomized, Double-Blinded, Multicenter, Placebo-Controlled Trial of Shenfu Injection for Treatment of Patients with Chronic Heart Failure during the Acute Phase of Symptom Aggravation (Yang and Qi Deficiency Syndrome). Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151652
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151652
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر