Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1αAkt Pathway in Liver Cancer
المؤلفون المشاركون
Chen, Qunwei
Cheng, Binbin
Ruan, Shanming
Lin, Wanfu
Ling, Changquan
Yin, Zifei
Zou, Yong
Liang, Shufang
Chen, Peifeng
Li, Shu
Shu, Qijin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In this study, we investigated whether melittin could suppress hypoxia-induced vasculogenic mimicry (VM) formation in liver cancer and explored the underlying mechanisms.
Melittin significantly inhibited the proliferation of liver cancer cells with or without CoCl2 presence.
Melittin also significantly inhibited CoCl2-induced migration, invasion, and VM formation of liver cancer cells.
CoCl2 treatment suppressed the expression of E-cadherin and elevated the expression of N-cadherin and Vimentin.
Melittin reversed the changes in the protein and mRNA levels of these epithelial-mesenchymal transition (EMT) markers.
CoCl2-induced accumulation of HIF-1α increased the level of phosphorylated Akt and upregulated the expression of VEGF and MMP-2/9.
Melittin decreased the HIF-1α level and thereby suppressed the levels of p-Akt, VEGF, and MMP-2/9.
In addition, the inhibitor of PI3K/Akt also suppressed CoCl2-induced EMT and liver cancer cells migration, and the activator of Akt, SC-79, partly blocked the effect of melittin on CoCl2-induced EMT and liver cancer cells migration.
In the xenograft tumor model in nude mice, melittin treatment significantly suppressed the tumor growth, VM formation, and HIF-1α expression in the tumor.
In conclusion, this study indicates melittin may inhibit hypoxia-induced VM formation and EMT in liver cancer through inhibiting HIF-1α/Akt pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Qunwei& Lin, Wanfu& Yin, Zifei& Zou, Yong& Liang, Shufang& Ruan, Shanming…[et al.]. 2019. Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1αAkt Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Qunwei…[et al.]. Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1αAkt Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Qunwei& Lin, Wanfu& Yin, Zifei& Zou, Yong& Liang, Shufang& Ruan, Shanming…[et al.]. Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1αAkt Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر