![](/images/graphics-bg.png)
Phytochemistry, Antioxidant Activity, Antiproliferative Effect, and Acute Toxicity Testing of Two Moroccan Aristolochia Species
المؤلفون المشاركون
Gmouh, Said
Benbacer, Laila
Ullah, Riaz
Bourhia, Mohammed
Bari, Ahmed
Ali, Syed Saeed
Moussa, Samir Iben
Khlil, Naima
Ait Haj Said, Amal
Laasri, Fatima Ezzahra
Kaoutar, Aghmih
El Mzibri, Mohamed
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ethnopharmacological Relevance.
Aristolochia baetica (A.
baetica) and Aristolochia paucinervis (A.
paucinervis) have been largely used in Moroccan folk medicine.
The objective of the study was to investigate the phytochemical composition, the antioxidant activity, the antiproliferative effect, and the acute toxicity of the methanolic extract of A.
baetica and A.
paucinervis roots.
Materials and Methods.
Phytochemical composition of the methanolic extract of A.
baetica and A.
paucinervis roots were studied using qualitative and quantitative methods, the antioxidant activity was evaluated using DPPH assay, the antiproliferative effects against human cancer cell lines (T-24, HT-29, and Hep G-2) was assessed using WST1 assay, and the acute toxicity was carried out orally by gavage of single dose 2000 mg/kg to mice for 14 days.
Results.
The two studied plants have different classes of secondary metabolites.
The concentrations of the total polyphenolic content of A.
baetica and A.
paucinervis root extracts were estimated at 360 ± 20 mg GAE/g and 280 ± 27 mg GAE/g, respectively.
The total flavonoids content of A.
baetica and A.
paucinervis extracts were estimated at 35 ± 8 mg QE/g and 235 ± 7 mg QE/g, respectively.
A.
baetica and A.
paucinervis extracts exhibited promising DPPH activity with IC50 values of 150 ± 8 μg/ml and 160 ± 10 μg/ml, respectively.
The extracts exerted also antiproliferative effects on all tested cancer cell lines (T-24, HT-29, and Hep G-2) with IC50 values ranging from 6 ± 1 μg/ml to 380 ± 7 μg/ml.
Regarding the results of acute toxicity study, no signs of toxicities nor mortalities were observed on the oral treated mice with 2000 mg/kg of the two investigated exacts.
Conclusion.
The methanolic extracts of A.
baetica and A.
paucinervis possess several phytochemicals that exhibited promising free radical scavenging activity and antiproliferative effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bourhia, Mohammed& Laasri, Fatima Ezzahra& Moussa, Samir Iben& Ullah, Riaz& Bari, Ahmed& Ali, Syed Saeed…[et al.]. 2019. Phytochemistry, Antioxidant Activity, Antiproliferative Effect, and Acute Toxicity Testing of Two Moroccan Aristolochia Species. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bourhia, Mohammed…[et al.]. Phytochemistry, Antioxidant Activity, Antiproliferative Effect, and Acute Toxicity Testing of Two Moroccan Aristolochia Species. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bourhia, Mohammed& Laasri, Fatima Ezzahra& Moussa, Samir Iben& Ullah, Riaz& Bari, Ahmed& Ali, Syed Saeed…[et al.]. Phytochemistry, Antioxidant Activity, Antiproliferative Effect, and Acute Toxicity Testing of Two Moroccan Aristolochia Species. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)