Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Liying
Wang, Ying
Zhang, Yongsheng
Lu, Wenting
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children.
The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) associated with pediatric MPP.
Methods.
This protocol has been registered (PROSPERO 2017: CRD42017077979).
A literature search was performed in October 2017 using PubMed, Embase, the Cochrane Library, and other Chinese medical databases to identify studies.
The meta-analysis was performed using Review Manager 5.3 software.
Random-effect models were used to estimate mean differences (MDs) and 95% confidence intervals (CIs) of cytokine levels.
Results.
Twelve studies were included in the meta-analysis, encompassing 2,422 children with MPP and 454 healthy control children.
Serum TNF-α levels were significantly higher in children with MPP compared with healthy children (MD = 22.5, 95% CI = 13.78–31.22, P<0.00001), and there was significant heterogeneity across studies (I2 = 100%, P<0.00001).
Subgroup analyses showed no evidence for a difference in serum TNF-α levels between children with refractory and nonrefractory MPP.
Serum IFN-γ levels did not significantly differ in children with MPP compared with healthy children (MD = 4.83, 95% CI = −3.27–12.93, P=0.24).
Conclusions.
Our meta-analysis showed that serum TNF-α and IFN-γ levels were significantly elevated and unchanged, respectively, in pediatric MPP.
Because infection by different pathogens has variable effects on serum TNF-α and IFN-γ levels, the finding could be helpful in developing novel diagnostic methods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ying& Zhang, Yongsheng& Lu, Wenting& Wang, Liying. 2018. Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1151885
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ying…[et al.]. Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1151885
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ying& Zhang, Yongsheng& Lu, Wenting& Wang, Liying. Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1151885
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151885
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر