A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice
المؤلفون المشاركون
Sun, Lifang
Mao, Minjie
Yan, Zhisheng
Zuo, Cuiyun
Zhang, Xiaojie
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Pulmonary fibrosis is a chronic and fatal disease of lung tissue with high incidence and mortality in the world.
The exploration of effective treatment for pulmonary fibrosis remains an urgent challenge.
In our study, Qingfei Xieding was investigated as a novel Chinese traditional patent medicine against pulmonary fibrosis.
A pulmonary fibrosis mouse model was constructed by injecting with bleomycin sulfate.
Following Qingfei Xieding administration, lung samples were collected to assess pulmonary phenotype changes by analyzing lung coefficient, wet/dry, and histopathologic section.
Levels of nitric oxide (NO), hydroxyproline (HYP), malondialdehyde (MDA), and total antioxidant capacity were measured to evaluate the degree of oxidation.
A single-cell gel electrophoresis (SCGE) assay was used to evaluate bleomycin-induced DNA damage.
Western blotting and real-time quantitative PCR were performed to determine the abundance of inducible nitric oxide synthase (iNOS), connective tissue growth factor (CTGF), alpha smooth muscle actin (α-SMA), and fibronectin (FN).
In the present study, Qingfei Xieding administration significantly attenuated bleomycin-induced pulmonary fibrosis in mice by reducing lung coefficient, wet/dry, NO, HYP, and MDA as well as the expression of iNOS, CTGF, α-SMA, FN, and DNA damage.
The results indicated that Qingfei Xieding is effective to resist oxidative damage and histopathologic lesion, serving a protection role on bleomycin-induced pulmonary fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Lifang& Mao, Minjie& Yan, Zhisheng& Zuo, Cuiyun& Zhang, Xiaojie. 2018. A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1151890
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Lifang…[et al.]. A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice. Canadian Respiratory Journal No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1151890
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Lifang& Mao, Minjie& Yan, Zhisheng& Zuo, Cuiyun& Zhang, Xiaojie. A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1151890
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151890
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر