Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in Rats
المؤلفون المشاركون
Lee, Donghun
Kim, Young-Sik
Song, Jungbin
Kim, Hocheol
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Musk of musk deer has been one of the most precious traditional medicinal materials for treatment of stroke, but trading is prohibited.
Musk of muskrat, Ondatra zibethicus, is an accessible substitute for musk of musk deer.
However, neuroprotective effects of the musk of muskrat on stroke model are so far unclear.
Aim of the study is to determine neuroprotective effects of the musk of muskrat on focal cerebral ischemia.
The protective effects against focal cerebral ischemia were evaluated using a model of middle cerebral artery occlusion (90-minute occlusion followed by 24-hour reperfusion).
Musk of muskrat was collected from scent bag of muskrat and orally administered at doses of 100 and 300 mg/kg twice at times of 0 and 90 min after occlusion.
The effects on sensorimotor dysfunction were investigated by using balance beam test and rotarod test after brain ischemia.
The expression of cyclooxygenase-2 (COX-2) was investigated by immunohistochemistry.
Oral administration of musk at 300 mg/kg significantly reduced (p<0.001) the infarct volume by 32.4% compared with a vehicle-treated group.
Oral administration of musk at 300 mg/kg also ameliorated ischemia-induced spontaneous and vestibule sensorimotor dysfunction in balance beam test and rotarod test compared with control group and COX-2 upregulation.
Musk of muskrat may have neuroprotective effects against transient focal cerebral ischemia with recovery of sensorimotor dysfunction.
Regarding the immunohistochemistry, the effects of muskrat may be due to anti-inflammatory properties through inhibition of COX-2 expressions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Donghun& Kim, Young-Sik& Song, Jungbin& Kim, Hocheol. 2019. Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151946
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Donghun…[et al.]. Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1151946
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Donghun& Kim, Young-Sik& Song, Jungbin& Kim, Hocheol. Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151946
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151946
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر