Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation

المؤلفون المشاركون

Alam, Mohammad Firoz
Sivakumar, Sivagurunathan Moni
Anwer, Tarique
Khan, Gyas
Safhi, Mohammed M.
Alshahrani, Saeed
Siddiqui, Rahimullah

المصدر

Cardiology Research and Practice

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-04-01

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض

الملخص EN

Thymoquinone is the active constituent of Nigella sativa, having antioxidant and anti-inflammatory actions.

In present study, we have analyzed the effects of thymoquinone on doxorubicin (DOX) induced cardiotoxicity in mice.

In this experiment, thirty mice (25–35 gm) were divided into five groups (Groups A, B, C, D, and E) each containing six animals.

Normal saline was given to a control group (Group A) for 14 days.

Cardiotoxicity was induced by DOX (15 mg/kg, i.p.) in Group B, once on the 13th day of the study, and Groups C and D also received DOX (15 mg/kg, i.p.) and were then treated with thymoquinone (10 and 20 mg/kg, b/w, p.o.), respectively, for 14 days.

Group E was given only thymoquione (20 mg/kg b/w, p.o.).

A blood serum marker (AST, ALT, CK-MB, and LDH) and oxidative stress marker (LPO, GSH, CAT, SOD, GPx, GR, and GST) were evaluated.

Results revealed that serum enzyme marker like aspartate aminotransferase (AST), creatinine kinase-MB (CKMB), and lactate dehydrogenase (LDH) were significantly elevated in Group B as compare to Group A.

Similarly, the oxidative stress marker lipid peroxidation (LPO) was also elevated in Group B while the antioxidant enzyme catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase (CAT, SOD, GPx, GR, and GST) were also decreased in Group B.

The treatment with thymoquinone 10 and 20 mg/kg resulted in a significant decrease in the serum marker and increase in the antioxidant enzymes.

In this study, we have found that thymoquinone prevented DOX-induced cardiotoxicity by accelerating heart antioxidant defense mechanisms and down regulating the LPO levels towards normalcy in Groups C and D.

The effect of doxorubicin increases the inflammatory cytokine (IL2) in Group B as compared to Group A, and it overcomes by the thymoquinone in Groups C and D.

Thus, thymoquinone may have utility as a potential drug for cardiomyopathy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Alam, Mohammad Firoz& Khan, Gyas& Safhi, Mohammed M.& Alshahrani, Saeed& Siddiqui, Rahimullah& Sivakumar, Sivagurunathan Moni…[et al.]. 2018. Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1151979

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Alam, Mohammad Firoz…[et al.]. Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation. Cardiology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1151979

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Alam, Mohammad Firoz& Khan, Gyas& Safhi, Mohammed M.& Alshahrani, Saeed& Siddiqui, Rahimullah& Sivakumar, Sivagurunathan Moni…[et al.]. Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1151979

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1151979