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Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients
المؤلفون المشاركون
Ibrahimi, Pranvera
Henein, Michael Y.
Rosa, Gian Marco
Dini, Frank Lloyd
Bajraktari, Gani
Pugliese, Nicola Riccardo
D’Agostino, Andreina
Perçuku, Luan
Miccoli, Mario
Galeotti, Gian Giacomo
Fabiani, Iacopo
Pedrinelli, Roberto
المصدر
Cardiology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Recent European Society of Cardiology and American Heart Association/American College of Cardiology Guidelines did not recommend biomarker-guided therapy in the management of heart failure (HF) patients.
Combination of echo- and B-type natriuretic peptide (BNP) may be an alternative approach in guiding ambulatory HF management.
Our aim was to determine whether a therapy guided by echo markers of left ventricular filling pressure (LVFP), lung ultrasound (LUS) assessment of B-lines, and BNP improves outcomes of HF patients.
Consecutive outpatients with LV ejection fraction (EF) ≤ 50% have been prospectively enrolled.
In Group I (n=224), follow-up was guided by echo and BNP with the goal of achieving E-wave deceleration time (EDT) ≥ 150 ms, tissue Doppler index E/e′ < 13, B-line numbers < 15, and BNP ≤ 125 pg/ml or decrease >30%; in Group II (n=293), follow-up was clinically guided, while the remaining 277 patients (Group III) did not receive any dedicated follow-up.
At 60 months, survival was 88% in Group I compared to 75% in Group II and 54% in Group III (χ2 53.5; p<0.0001).
Survival curves exhibited statistically significant differences using Mantel–Cox analysis.
The number needed to treat to spare one death was 7.9 (Group I versus Group II) and 3.8 (Group I versus Group III).
At multivariate Cox regression analyses, major predictors of all-cause mortality were follow-up E/e′ (HR: 1.05; p=0.0038) and BNP >125 pg/ml or decrease ≤30% (HR: 4.90; p=0.0054), while BNP > 125 pg/ml or decrease ≤30% and B-line numbers ≥15 were associated with the combined end point of death and HF hospitalization.
Evidence-based HF treatment guided by serum biomarkers and ultrasound with the goal of reducing elevated BNP and LVFP, and resolving pulmonary congestion was associated with better clinical outcomes and can be valuable in guiding ambulatory HF management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bajraktari, Gani& Pugliese, Nicola Riccardo& D’Agostino, Andreina& Rosa, Gian Marco& Ibrahimi, Pranvera& Perçuku, Luan…[et al.]. 2018. Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1152019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bajraktari, Gani…[et al.]. Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients. Cardiology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1152019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bajraktari, Gani& Pugliese, Nicola Riccardo& D’Agostino, Andreina& Rosa, Gian Marco& Ibrahimi, Pranvera& Perçuku, Luan…[et al.]. Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1152019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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