Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

المؤلفون المشاركون

Sun, Jia-Qi
Jia, Xiaopeng
Chen, Zhen
Liu, Genglong
Wei, Xuxia
Tai, Qiang
Zheng, Donghua
Xie, Wenfeng
Chen, Li
Wang, Ganping
Wang, Siqi
Liu, Na
Lv, Haijin

المصدر

Emergency Medicine International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-07-18

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Objectives.

Driving pressure (DP) has recently become a promising mediator for the identification of the effects of mechanical ventilation on outcomes in acute respiratory distress syndrome (ARDS).

The aim of this study was to systematically and quantitatively update and assess the association between DP and mortality among ventilated patients with ARDS.

Methods.

PubMed, the Cochrane Library, ISI Web of Knowledge, and Embase were systematically searched from inception to June 2018.

Two investigators conducted the literature search study selection, data extraction, and quality evaluation independently.

RevMan 5.3 software was used for all statistical analyses.

Results.

A total of seven studies comprising 8010 patients were included in this meta-analysis.

Higher DP showed a significant association with higher mortality (pooled risk ratio, 1.10; 95% [CI], 1.05–1.16; I2 =58%).

Sensitivity analysis indicated that one study significantly affected the stability of pooled results.

One of the subgroups investigated, ARDS severity, could account for the heterogeneity.

An exploratory post hoc subgroup analysis and higher DP significantly increased mortality in the mild to severe ARDS subgroup (RR 1.28; 95% [CI], 1.14–1.43; I2 =0), but not in the moderate to severe ARDS subgroup (RR 1.18; 95% [CI], 0.95–1.46; I2 =52%).

Conclusion.

Higher DP was significantly associated with an increased risk of death among ventilated patients with ARDS.

But it did not seem to predict prognosis to moderate to severe ARDS.

Future prospective randomized clinical trials are needed to verify the results of this meta-analysis and address the unresolved questions about optimum cutoff values for DP.

Trial Registration.

This trial is registered with PROSPERO (CRD42018102146), on 11 August 2018.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Zhen& Wei, Xuxia& Liu, Genglong& Tai, Qiang& Zheng, Donghua& Xie, Wenfeng…[et al.]. 2019. Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Emergency Medicine International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1152214

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Zhen…[et al.]. Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Emergency Medicine International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1152214

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Zhen& Wei, Xuxia& Liu, Genglong& Tai, Qiang& Zheng, Donghua& Xie, Wenfeng…[et al.]. Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Emergency Medicine International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1152214

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1152214