Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Xu, Liyan
Li, Enmin
Li, Lan
Liu, Ming
Lin, Jian-Bang
Hong, Xin-Bin
Chen, Wen-Xia
Guo, Hong
Xu, Yi-Wei
Peng, Yu-Hui
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Esophageal squamous cell carcinoma (ESCC), one of the most common malignancies worldwide, is a highly aggressive and homogeneous entity occurring in esophageal squamous epithelium, and a reliable noninvasive test for early detection is needed.
A recent study showed that serum autoantibodies against Ezrin could be detected in patients with pancreatic cancer.
Here, we assessed whether autoantibodies against Ezrin could have diagnostic relevance for early ESCC.
We analyzed autoantibodies against Ezrin in sera of 98 normal controls and 149 patients with ESCC.
Ezrin autoantibodies levels were evaluated by enzyme-linked immunosorbent assay (ELISA).
Results showed that higher levels of autoantibodies against Ezrin were observed in serum samples from patients with ESCC than in serum from normal controls ( P < 0.0001 ).
Based on a cutoff value of 0.319, the sensitivity and specificity of autoantibodies against Ezrin for diagnosis of ESCC were 27.5% and 95.9%, respectively.
Compared with normal controls, the positive rate of autoantibodies against Ezrin was significantly elevated in patients with early-stage ESCC ( P < 0.0001 ).
Moreover, there was no significant difference of positivity of autoantibodies against Ezrin in ESCC patients categorized according to age, gender, tumor size, tumor invasion depth, tumor site, histological grade, lymph node status, or tumor stage.
Our study indicates that the presence of autoantibodies against Ezrin is significantly associated with ESCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Lan& Liu, Ming& Lin, Jian-Bang& Hong, Xin-Bin& Chen, Wen-Xia& Guo, Hong…[et al.]. 2017. Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152232
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Lan…[et al.]. Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152232
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Lan& Liu, Ming& Lin, Jian-Bang& Hong, Xin-Bin& Chen, Wen-Xia& Guo, Hong…[et al.]. Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152232
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152232
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر