Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models
المؤلفون المشاركون
Yashiro, Masato
Yamada, Mutsuko
Nosaka, Nobuyuki
Morishima, Tsuneo
Tsukahara, Hirokazu
Nagaoka, Yoshiharu
Washio, Yosuke
Baba, Kenji
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To compare local and systemic profiles between different disease pathologies (pneumonia and encephalitis) induced by influenza A virus (IAV).
Methods.
An IAV pneumonia model was created by intranasal inoculation of C57BL/6 mice with influenza A/WSN/33 (H1N1) virus.
Lung lavage and blood collection were performed on day 3 after IAV inoculation.
Similarly, an IAV encephalitis mouse model was created by direct intracranial IAV inoculation.
Cerebrospinal fluid (CSF) and blood collection were conducted according to the same schedule.
Cytokine/chemokine profiles were produced for each collected sample.
Then the data were compared visually using radar charts.
Results.
Serum cytokine profiles were similar in pneumonia and encephalitis models, but local responses between the bronchoalveolar lavage fluid (BALF) in the pneumonia model and CSF in the encephalitis model differed.
Moreover, to varying degrees, the profiles of local cytokines/chemokines differed from those of serum in both the pneumonia and encephalitis models.
Conclusion.
Investigating local samples such as BALF and CSF is important for evaluating local immune responses, providing insight into pathology at the primary loci of infection.
Serum data alone might be insufficient to elucidate local immune responses and might not enable clinicians to devise the most appropriate treatment strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nagaoka, Yoshiharu& Nosaka, Nobuyuki& Yamada, Mutsuko& Yashiro, Masato& Washio, Yosuke& Baba, Kenji…[et al.]. 2017. Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nagaoka, Yoshiharu…[et al.]. Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nagaoka, Yoshiharu& Nosaka, Nobuyuki& Yamada, Mutsuko& Yashiro, Masato& Washio, Yosuke& Baba, Kenji…[et al.]. Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر