miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma
المؤلفون المشاركون
Deng, Xinchao
Hou, Congzhe
Liang, Zhen
Wang, Huali
Zhu, Lin
Xu, Hui
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
MicroRNA-202 (miR-202) has been reported to be aberrantly regulated in several cancers.
The aim of this study is to explore the functional role of miR-202 in EAC tumor growth.
Material and Methods.
miR-202 expression was detected by qRT-PCR.
TargetScan and luciferase reporter assay were used to elucidate the candidate target gene of miR-202.
The FOXR2 protein level was assessed by Western blot and immunohistochemistry.
Survival analysis was explored for FOXR2 expression in EAC patients.
Results.
miR-202 expression was significantly decreased in EAC tissues (P<0.01) compared with that in control tissues.
And the downregulate miR-202 was significantly associated with poor prognosis (P<0.01).
Re-expression of miR-202 dramatically suppressed cell proliferation in vitro and tumor growth in vivo.
FOXR2 was identified as a direct target of miR-202.
In EAC tissues, FOXR2 was upregulated and the increased FOXR2 was significantly associated with poor prognosis.
In miR-202-transfected cells, the FOXR2 expression was inversely changed.
The analysis of FOXR2 protein expression and miR-202 transcription in EAC tissues showed negative correlation (R=−0.429).
Conclusion.
miR-202 may function as a tumor suppressor in EAC tumor growth by targeting FOXR2 oncogene, which may provide new insights into the molecular mechanism and new targets for treatment of EAC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Xinchao& Hou, Congzhe& Liang, Zhen& Wang, Huali& Zhu, Lin& Xu, Hui. 2017. miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152261
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Xinchao…[et al.]. miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152261
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Xinchao& Hou, Congzhe& Liang, Zhen& Wang, Huali& Zhu, Lin& Xu, Hui. miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152261
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152261
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر