Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance
المؤلفون المشاركون
Liu, Juan
Xing, Xiangbin
Wu, Xinlin
Li, Xiang
Yao, Shun
Ren, Zi
Zeng, Haitao
Wu, Shaohong
المصدر
Cardiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Individuals at a prediabetic stage have had an augmented cardiovascular disease (CVD) risk and CVD-related mortality compared to normal glucose tolerance (NGT) individuals, which may be attributed to the impaired vascular endothelial repair capacity.
In this study, circulating endothelial progenitor cells’ (EPCs) number and activity were evaluated, and the underlying mechanisms in premenopausal women with impaired glucose regulation were explored.
Methods.
Circulating EPCs’ number and activity and flow-mediated dilation (FMD) were compared in premenopausal women with NGT, isolated impaired fasting glucose (i-IFG), or isolated impaired glucose tolerance (i-IGT).
Plasma nitric oxide (NO), EPCs-secreted NO, and intracellular BH4 levels were also measured.
The key proteins (Tie2, Akt, eNOS, and GTPCH I) in the guanosine triphosphate cyclohydrolase/tetrahydrobiopterin (GTPCH/BH4) pathway and Tie2/Akt/eNOS signaling pathway were evaluated in these women.
Results.
It was observed that the i-IGT premenopausal women not i-IFG premenopausal women had a significant reduction in circulating EPCs’ number and activity as well as reduced FMD when compared to NGT subjects.
Plasma NO levels or EPCs-secreted NO also decreased only in i-IGT women.
The expression of GTCPH I as well as intracellular BH4 levels declined in i-IGT women; however, the alternations of key proteins’ expression in the Tie2/Akt/eNOS signaling pathway were not observed in either i-IGT or i-IFG women.
Conclusions.
The endothelial repair capacity was impaired in i-IGT premenopausal women but was preserved in i-IFG counterparts.
The underlying mechanism may be associated with the downregulated GTCPH I pathway and reduced NO productions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Juan& Xing, Xiangbin& Wu, Xinlin& Li, Xiang& Yao, Shun& Ren, Zi…[et al.]. 2020. Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1152313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Juan…[et al.]. Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance. Cardiology Research and Practice No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1152313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Juan& Xing, Xiangbin& Wu, Xinlin& Li, Xiang& Yao, Shun& Ren, Zi…[et al.]. Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1152313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر