Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance
المؤلفون المشاركون
Geng, Jianping
Zhang, Xiaomeng
Chang, Pan
Lei, Shengping
Wang, Jianbang
Chen, Baoying
Yu, Jun
Zhang, Jing
Wu, Juan
Wang, Xihui
المصدر
Cardiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Brain natriuretic peptide (BNP) is an important biological marker and regulator of cardiac function.
BNP resistance is characterized by high concentrations of less functionally effective BNP and common in heart failure (HF) patients.
However, the roles and consequences of BNP resistance remain poorly understood.
Investigate the effects of cardiac BNP resistance and identify potential metabolic biomarkers for screening and diagnosis.
Thirty patients and thirty healthy subjects were enrolled in this study.
Cardiac functions were evaluated by echocardiography.
The plasma levels of cyclic guanosine monophosphate (cGMP) and BNP were measured by enzyme-linked immunosorbent assay (ELISA) and the cGMP/BNP ratio is calculated to determine cardiac natriuretic peptide resistance.
Liquid chromatograph tandem mass spectrometry (LC-MS) based untargeted metabolomics analysis was applied to screen metabolic changes.
The cGMP/BNP ratio was markedly lower in HF patients than controls.
The cGMP/BNP ratio and ejection fraction (EF) were strongly correlated (R2 = 0.676, P<0.05).
Importantly, metabolic profiles were substantially different between HF patients and healthy controls.
Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the differentially expressed metabolites are involved in signaling pathways that regulate cardiac functions.
In HF patients, BNP resistance develops in association with a reduction in heart function and metabolic remodeling.
It suggests possible functional roles of BNP resistance in the regulation of cardiac metabolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Pan& Lei, Shengping& Zhang, Xiaomeng& Zhang, Jing& Wang, Xihui& Wu, Juan…[et al.]. 2020. Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1152328
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Pan…[et al.]. Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance. Cardiology Research and Practice No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1152328
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Pan& Lei, Shengping& Zhang, Xiaomeng& Zhang, Jing& Wang, Xihui& Wu, Juan…[et al.]. Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1152328
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152328
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر