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Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2
المؤلفون المشاركون
Gala-Błądzińska, Agnieszka
Braun, Marcin
Romanek, Janusz
Mazur, Danuta
Stepek, Tomasz
Szafarz, Piotr
Chlebuś, Marcin
Przybylski, Andrzej
المصدر
Cardiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Patients with chronic cardiorenal syndrome type 2 (T2-CRS) who qualify for resynchronization therapy (CRT) are exposed perioperatively to potentially nephrotoxic factors including contrast agents and blood loss.
Methods.
The objective of this prospective interventional study was to assess the effects of CRT on renal function in patients with T2-CRS within the first 48 hours following implantation.
Initially, 76 patients (15% female; aged 69 ± 9.56 years) with heart failure (New York Heart Association classes II–IV), ejection fraction ≤ 35%, and QRS > 130 ms were included in the study.
During CRT implantation, a nonionic contrast agent (72.2 ± 44.9 mL) was administered.
Prior to and 48 hours following implantation, renal function was evaluated using the following serum biomarkers: creatinine (sCr), estimated glomerular filtration rate (using the Chronic Kidney Disease Epidemiology Collaboration equation [eGFRCKD-EPI]), and the electrolyte and urine biomarkers albumin (uAlb), albumin/creatinine ratio (UACR), and neutrophil gelatinase-associated lipocalin (uNGAL).
Results.
Before CRT, patients classified as NYHA class III or IV had higher uNGAL levels in comparison to uNGAL levels after CRT (43.63 ± 60.02 versus 16.63 ± 18.19; p=0.041).
After CRT implantation, uAlb, UACR, and potassium levels were reduced (p<0.05), and uNGAL, sCr, and eGFRCKD-EPI were unchanged.
The contrast medium volume did not correlate with the test biomarkers (p>0.05).
Conclusions.
In patients with T2-CRS, uNGAL is a biomarker of kidney injury that correlates with the NYHA classes.
A stable uNGAL value before and after CRT implantation confirms the lack of risk of contrast-induced nephropathy.
Reduced albuminuria and blood potassium are biomarkers of improving T2-CRS in the early post-CRT period.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gala-Błądzińska, Agnieszka& Romanek, Janusz& Mazur, Danuta& Stepek, Tomasz& Braun, Marcin& Szafarz, Piotr…[et al.]. 2020. Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gala-Błądzińska, Agnieszka…[et al.]. Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2. Cardiology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1152380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gala-Błądzińska, Agnieszka& Romanek, Janusz& Mazur, Danuta& Stepek, Tomasz& Braun, Marcin& Szafarz, Piotr…[et al.]. Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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