Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis
المؤلفون المشاركون
Comi, Cristoforo
Brigo, Francesco
Clemente, Nausicaa
Lochner, Piergiorgio
Cantello, Roberto
Lesmeister, Martin
Naldi, Andrea
Coppo, Lorenzo
Nardone, Raffaele
Fassbender, Klaus
Siniscalchi, Antonio
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background and Objective.
To investigate the relationship between optic nerve sheath diameter, optic nerve diameter, visual acuity and osteopontin, and neurofilament heavy chain in patients with acute optic neuritis.
Patients and Methods.
Sonographic and visual acuity assessment and biomarker measurements were executed in 23 patients with unilateral optic neuritis and in 19 sex- and age-matched healthy controls.
Results.
ONSD was thicker on the affected side at symptom onset (median 6.3 mm; interquartile range 6.0–6.5) than after 12 months (5.3 mm; 4.9–5.6; p<0.001) or than in controls (5.2 mm; 4.8–5.5; p<0.001).
OND was significantly increased in the affected side (3.4 mm; 2.9–3.8) compared to healthy controls (2.7 mm; 2.5–2.9; p<0.001) and was thicker at baseline than after 12 months (2.8 mm; 2.7–3.0; p<0.01).
Visual acuity improved significantly after 12 months (1.00; 0.90–1.00) compared to onset of symptoms (0.80; 0.40–1.00; p<0.001).
OPN levels were significantly higher in patients at presentation (median 6.44 ng/ml; 2.05–10.06) compared to healthy controls (3.21 ng/ml, 1.34–4.34; p<0.03).
Concentrations of NfH were significantly higher in patients than in controls.
Conclusion.
ONSD and OND are increased in the affected eye.
OPN and NfH are elevated in patients, confirming the presence of any underlying inflammation and axonal injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lochner, Piergiorgio& Cantello, Roberto& Fassbender, Klaus& Lesmeister, Martin& Nardone, Raffaele& Siniscalchi, Antonio…[et al.]. 2017. Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lochner, Piergiorgio…[et al.]. Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lochner, Piergiorgio& Cantello, Roberto& Fassbender, Klaus& Lesmeister, Martin& Nardone, Raffaele& Siniscalchi, Antonio…[et al.]. Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر