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DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome
المؤلفون المشاركون
Abujamra, Ana Lucia
Dexheimer, Geórgia Muccillo
Alves, Jayse
Reckziegel, Laura
Lazzaretti, Gabrielle
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
During the onset and progression of hematological malignancies, many changes occur in cellular epigenome, such as hypo- or hypermethylation of CpG islands in promoter regions.
DNA methylation is an epigenetic modification that regulates gene expression and is a key event for tumorigenesis.
The continuous search for biomarkers that signal early disease, indicate prognosis, and act as therapeutic targets has led to studies investigating the role of DNA in cancer onset and progression.
This review focuses on DNA methylation changes as potential biomarkers for diagnosis, prognosis, response to treatment, and early toxicity in acute myeloid leukemia and myelodysplastic syndrome.
Here, we report that distinct changes in DNA methylation may alter gene function and drive malignant cellular transformation during several stages of leukemogenesis.
Most of these modifications occur at an early stage of disease and may predict myeloid/lymphoid transformation or response to therapy, which justifies its use as a biomarker for disease onset and progression.
Methylation patterns, or its dynamic change during treatment, may also be used as markers for patient stratification, disease prognosis, and response to treatment.
Further investigations of methylation modifications as therapeutic biomarkers, which may correlate with therapeutic response and/or predict treatment toxicity, are still warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dexheimer, Geórgia Muccillo& Alves, Jayse& Reckziegel, Laura& Lazzaretti, Gabrielle& Abujamra, Ana Lucia. 2017. DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome. Disease Markers،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dexheimer, Geórgia Muccillo…[et al.]. DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome. Disease Markers No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1152388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dexheimer, Geórgia Muccillo& Alves, Jayse& Reckziegel, Laura& Lazzaretti, Gabrielle& Abujamra, Ana Lucia. DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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