Plasmatic Soluble Receptor for Advanced Glycation End Products as a New Oxidative Stress Biomarker in Patients with Prosthetic-Joint-Associated Infections?
المؤلفون المشاركون
Drago, Lorenzo
Goi, G.
Corsi Romanelli, Massimiliano M.
Bonomelli, Barbara
Marazzi, Monica Gioia
Erba, Daniela
Papini, Nadia
Galliera, Emanuela
Massaccesi, L.
Barassi, A.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking.
Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAGE).
The aim of this study was to evaluate plasmatic soluble receptor for advanced glycation end products (sRAGE), as a new OS and infection marker correlating sRAGE to the level of OS and antioxidant defenses, in PJI, in order to explore the possible application of this new biomarker in the early diagnosis of PJI.
Plasmatic sRAGE levels (by ELISA assay), plasma antioxidant total defenses (by lag time method), plasma reactive oxygen species (ROS), and thiobarbituric acid reactive substance (TBARS) levels (by colorimetric assay) were evaluated in 11 PJI patients and in 30 matched controls.
ROS and TBARS were significantly higher (p<0.001) while plasma total antioxidant capacity and sRAGE were significantly lower (p<0.01) in patients with PJI compared to controls.
Our results confirm the OS in PJI and show a strong negative correlation between the level of sRAGE and oxidative status, suggesting the plasmatic sRAGE as a potential marker for improving PJI early diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Massaccesi, L.& Bonomelli, Barbara& Marazzi, Monica Gioia& Drago, Lorenzo& Corsi Romanelli, Massimiliano M.& Erba, Daniela…[et al.]. 2017. Plasmatic Soluble Receptor for Advanced Glycation End Products as a New Oxidative Stress Biomarker in Patients with Prosthetic-Joint-Associated Infections?. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Massaccesi, L.…[et al.]. Plasmatic Soluble Receptor for Advanced Glycation End Products as a New Oxidative Stress Biomarker in Patients with Prosthetic-Joint-Associated Infections?. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Massaccesi, L.& Bonomelli, Barbara& Marazzi, Monica Gioia& Drago, Lorenzo& Corsi Romanelli, Massimiliano M.& Erba, Daniela…[et al.]. Plasmatic Soluble Receptor for Advanced Glycation End Products as a New Oxidative Stress Biomarker in Patients with Prosthetic-Joint-Associated Infections?. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر