Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients
المؤلفون المشاركون
Arsenijevic, Nebojsa
Lukic, Ruzica
Gajovic, Nevena
Jovanovic, Ivan
Jurisevic, Milena
Mijailovic, Zeljko
Maric, Veljko
Popovska Jovicic, Biljana
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hepatitis C virus infection (HCV), one of the greatest causes of liver disease, is a frequent complication in patients with end-stage renal disease (ESRD) on dialysis.
ESRD is defined as decreased glomerular filtration and also accompanied by impaired function of the immune system.
Galectin-3 is a β-galactoside-binding lectin, involved in various biological processes including pathogenesis of chronic renal disease.
The aim of our study was to estimate disease severity in ESRD HCV+ patients and analyze the serum concentrations of IL-1β, IL-4, IL-23, and IL-6; anti-HCV antibodies; and galectin-3.
Also, we attempted to determine potential correlation between galectin-3 level and parameters of disease severity ALT and AST.
Our results showed decreased levels of ALT and AST (p=0.00), demonstrating less liver destruction in ESRD HCV+ patients in comparison to HCV+ patients.
Increased levels of IL-6 (p=0.03) implicate a hepatoprotective role of IL-6 in these patients.
Also, level of galectin-3 (p=0.00) in the serum of ESRD HCV+ patients was higher than that of HCV+ patients.
This alteration was accompanied with negative correlation between galectin-3 and AST and ALT, respectively (p=0.029; p=0.033).
The presence of increased systemic levels of IL-6 and Gal-3 in ESRD HCV+ patients may be an attempt to counteract or limit ongoing proinflammatory processes and to downregulate chronic inflammation, suggesting the new aspects of HCV infection in ESRD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lukic, Ruzica& Gajovic, Nevena& Jovanovic, Ivan& Jurisevic, Milena& Mijailovic, Zeljko& Maric, Veljko…[et al.]. 2017. Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lukic, Ruzica…[et al.]. Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lukic, Ruzica& Gajovic, Nevena& Jovanovic, Ivan& Jurisevic, Milena& Mijailovic, Zeljko& Maric, Veljko…[et al.]. Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر