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Are Fusion Transcripts in RelapsedMetastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?
المؤلفون المشاركون
Pilotti, Silvana
Canevari, Silvana
Bossi, Paolo
Siano, Marco
Bergamini, Cristiana
Sponghini, Andrea P.
Giannoccaro, Marco
Tonella, Luca
Paoli, Alessandro
Marchesi, Edoardo
Perrone, Federica
Locati, Laura D.
De Cecco, Loris
Cossu Rocca, Maria
Licitra, Lisa
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Prediction of benefit from combined chemotherapy and the antiepidermal growth factor receptor cetuximab is a not yet solved question in head and neck squamous cell carcinoma (HNSCC).
In a selected series of 14 long progression-free survival (PFS) and 26 short PFS patients by whole gene and microRNA expression analysis, we developed a model potentially predictive of cetuximab sensitivity.
To better decipher the “omics” profile of our patients, we detected transcript fusions by RNA-seq through a Pan-Cancer panel targeting 1385 cancer genes.
Twenty-seven different fusion transcripts, involving mRNA and long noncoding RNA (lncRNA), were identified.
The majority of fusions (81%) were intrachromosomal, and 24 patients (60%) harbor at least one of them.
The presence/absence of fusions and the presence of more than one fusion were not related to outcome, while the lncRNA-containing fusions resulted enriched in long PFS patients (P=0.0027).
The CD274-PDCD1LG2 fusion was present in 7/14 short PFS patients harboring fusions and was absent in long PFS patients (P=0.0188).
Among the short PFS patients, those harboring this fusion had the worst outcome (P=0.0172) and increased K-RAS activation (P=0.00147).
The associations between HNSCC patient’s outcome following cetuximab treatment and lncRNA-containing fusions or the CD274-PDCD1LG2 fusion deserve validation in prospective clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bossi, Paolo& Siano, Marco& Bergamini, Cristiana& Cossu Rocca, Maria& Sponghini, Andrea P.& Giannoccaro, Marco…[et al.]. 2017. Are Fusion Transcripts in RelapsedMetastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bossi, Paolo…[et al.]. Are Fusion Transcripts in RelapsedMetastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bossi, Paolo& Siano, Marco& Bergamini, Cristiana& Cossu Rocca, Maria& Sponghini, Andrea P.& Giannoccaro, Marco…[et al.]. Are Fusion Transcripts in RelapsedMetastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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