Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome
المؤلفون المشاركون
Cheng, Long-xian
Jiang, Lili
Chen, Feng
Hu, Xiaofan
Hu, Yingying
Wang, Yange
Zhang, Wenyong
Peng, Yudong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS).
However, there is debate about which Treg subsets are truly critical to ACS.
Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is known about its role in ACS.
We therefore examined Helios+ Tregs in patients with ACS, patients with stable angina, and control subjects.
73 patients with ACS, 30 patients with stable angina, and 48 control subjects were enrolled.
The frequencies and estimated absolute numbers of different Treg subsets in peripheral blood were measured by flow cytometry.
Plasma cytokine level was measured by ELISA.
The mRNA expression of Foxp3 and Helios in purified CD4+ T cells was determined by RT-PCR.
Helios+ Tregs was decreased significantly in patients with ACS.
The frequency and estimated absolute numbers of CD4+Foxp3+Helios+ Tregs were negatively correlated with IL-6 and positively correlated with circulating level of TGF-beta1 and HDL-C.
The mRNA expression of Foxp3 and Helios was decreased in CD4+ T cells from patients with ACS.
In summary, Helios+ Tregs was downregulated in patients with ACS and may play a role in ACS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Lili& Chen, Feng& Hu, Xiaofan& Hu, Yingying& Wang, Yange& Zhang, Wenyong…[et al.]. 2017. Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152505
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Lili…[et al.]. Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152505
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Lili& Chen, Feng& Hu, Xiaofan& Hu, Yingying& Wang, Yange& Zhang, Wenyong…[et al.]. Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152505
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152505
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر