Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia
المؤلفون المشاركون
Hartopo, Anggoro Budi
Setianto, Budi Yuli
Dinarti, Lucia Kris
Anggrahini, Dyah Wulan
Sadewa, Ahmad Hamim
Wahab, Abdus Samik
المصدر
Cardiology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Objectives.
Pulmonary arterial hypertension (PAH) pathomechanism involves an increased plasma level of endothelin-1 and a reduced plasma level of prostacyclin and nitric oxide.
Whether similar mechanisms prevail in PAH associated with atrial septal defect (ASD) is unclear.
This study aimed to investigate the relationship of endothelin-1, prostacyclin, and nitric oxide with PAH in uncorrected ASD in Indonesian population.
Methods.
The study design was cross-sectional.
The subjects were adult uncorrected secundum ASD with PAH.
Pulmonary artery pressure was measured with right heart catheterization.
Pulmonary venous blood was obtained during catheterization for measuring endothelin-1, prostacyclin, and nitric oxide.
Correlation tests were performed to determine any association between biomarkers and mean pulmonary artery pressure (mPAP).
The levels of biomarkers were compared based on the severity of PAH.
Statistical significance was determined at p<0.05.
Results.
Forty-four subjects were enrolled in this study.
Endothelin-1 level and mPAP had significant moderate positive correlation (r = 0.423 and p value = 0.004).
However, no significant correlation was observed between prostacyclin, nitric oxide levels, and mPAP.
The pattern of endothelin-1, prostacyclin, and nitric oxide was distinctive.
Levels of endothelin-1 were incrementally increased from mild, moderate, to severe PAH.
The levels of prostacyclin and nitric oxide had similar pattern in association with the severity of PAH, which was increased in mild-to-moderate PAH but decreased in severe PAH.
Conclusions.
There was a distinctive pattern of endothelin-1, prostacyclin, and nitric oxide based on severity of PAH in adult uncorrected ASD.
Significant correlations existed between endothelin-1 and the severity of PAH and mPAP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dinarti, Lucia Kris& Hartopo, Anggoro Budi& Anggrahini, Dyah Wulan& Sadewa, Ahmad Hamim& Setianto, Budi Yuli& Wahab, Abdus Samik. 2020. Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dinarti, Lucia Kris…[et al.]. Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia. Cardiology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1152582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dinarti, Lucia Kris& Hartopo, Anggoro Budi& Anggrahini, Dyah Wulan& Sadewa, Ahmad Hamim& Setianto, Budi Yuli& Wahab, Abdus Samik. Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر