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Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma
المؤلفون المشاركون
Kafka, Anja
Tomas, Davor
Lechpammer, Mirna
Gabud, Tea
Pažanin, Leo
Pećina-Šlaus, Nives
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The expression patterns of critical molecular components of Wnt signaling, sFRP3 and DVL3, were investigated in glioblastoma, the most aggressive form of primary brain tumors, with the aim to offer potential biomarkers.
The protein expression levels and localizations in tumor tissue were revealed by immunohistochemistry and evaluated by the semiquantitative method and immunoreactivity score.
Majority of glioblastomas had moderate expression levels for both DVL3 (52.4%) and sFRP3 (52.3%).
Strong expression levels were observed in 23.1% and 36.0% of samples, respectively.
DVL3 was localized in cytoplasm in 97% of glioblastomas, of which 44% coexpressed the protein in the nucleus.
sFRP3 subcellular distribution showed that it was localized in the cytoplasm in 94% of cases.
Colocalization in the cytoplasm and nucleus was observed in 50% of samples.
Wilcox test indicated that the domination of the strong signal is in connection with simultaneous localization of DVL3 protein in the cytoplasm and the nucleus.
Patients with strong expression of DVL3 will significantly more often have the protein in the nucleus (P=6.33×10−5).
No significant correlation between the two proteins was established, nor were their signal strengths correlated with epidemiological parameters.
Our study contributes to better understanding of glioblastoma molecular profile.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kafka, Anja& Tomas, Davor& Lechpammer, Mirna& Gabud, Tea& Pažanin, Leo& Pećina-Šlaus, Nives. 2017. Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kafka, Anja…[et al.]. Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kafka, Anja& Tomas, Davor& Lechpammer, Mirna& Gabud, Tea& Pažanin, Leo& Pećina-Šlaus, Nives. Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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