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A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk
المؤلفون المشاركون
Ran, Guimei
Wang, Yixuan
Liu, Haochen
Wei, Chunxiang
Zhu, Tao
Wang, Haidong
He, Hua
Liu, Xiaoquan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
The study was designed to evaluate the disease outcome based on multiple biomarkers related to cerebral ischemia.
Methods.
Rats were randomly divided into sham, permanent middle cerebral artery occlusion, and edaravone-treated groups.
Cerebral ischemia was induced by permanent middle cerebral artery occlusion surgery in rats.
To form a simplified crosstalk network, the related multiple biomarkers were chosen as S100β, HIF-1α, IL-1β, PGI2, TXA2, and GSH-Px.
The levels or activities of these biomarkers in plasma were detected before and after ischemia.
Concurrently, neurological deficit scores and cerebral infarct volumes were assessed.
Based on a mathematic model, network balance maps and three integral disruption parameters (k, φ, and u) of the simplified crosstalk network were achieved.
Results.
The levels or activities of the related biomarkers and neurological deficit scores were significantly impacted by cerebral ischemia.
The balance maps intuitively displayed the network disruption, and the integral disruption parameters quantitatively depicted the disruption state of the simplified network after cerebral ischemia.
The integral disruption parameter u values correlated significantly with neurological deficit scores and infarct volumes.
Conclusion.
Our results indicate that the approach based on crosstalk network may provide a new promising way to integrally evaluate the outcome of cerebral ischemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ran, Guimei& Wang, Yixuan& Liu, Haochen& Wei, Chunxiang& Zhu, Tao& Wang, Haidong…[et al.]. 2017. A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ran, Guimei…[et al.]. A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ran, Guimei& Wang, Yixuan& Liu, Haochen& Wei, Chunxiang& Zhu, Tao& Wang, Haidong…[et al.]. A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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