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Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction
المؤلفون المشاركون
Ottomann, Christian
Küntscher, Markus
Hartmann, Bernd
Antonic, Vlado
المصدر
Dermatology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ischaemic insult in the skin flaps is a major problem in reconstructive surgery particularly in patients with diabetes mellitus.
Here, we sought to investigate the effectiveness of ischaemic preconditioning (IP) on diabetic skin flaps in rat animal model.
Hundred Wistar rats (90 streptozotocin treated animals and 10 nondiabetic controls) were used.
Diabetes mellitus was confirmed by measuring glucose level in blood, HbA1c, and ketonuria.
We used blood vessel clamping, hind limb tourniquet, and NO donors (Spermine/NO complex) to induce short-term ischaemia of tissues that will be excised for skin flaps.
Animals were followed for 5 days.
Flaps were photographed at day 5 and percent of necrosis was determined using planimetry.
Significant decrease in percent of necrotic tissue in all groups that received preconditioning was observed.
Results show that ischaemic preconditioning suppresses flap necrosis in diabetic rats irrespective of direct or remote tissue IP and irrespective of chemically or physically induced preischaemia.
Spermine/NO complex treatment 10 minutes after the flap ischaemia suppressed tissue necrosis.
Treatment with NO synthase inhibitor L-NAME reversed effects of IP showing importance of NO for this process.
We show that IP is a promising approach for suppression of tissue necrosis in diabetic flaps and potential of NO pathway as therapeutic target in diabetic flaps.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ottomann, Christian& Küntscher, Markus& Hartmann, Bernd& Antonic, Vlado. 2017. Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction. Dermatology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ottomann, Christian…[et al.]. Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction. Dermatology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ottomann, Christian& Küntscher, Markus& Hartmann, Bernd& Antonic, Vlado. Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction. Dermatology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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