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Histological and Immunohistochemical Evaluation of the Efficacy of a New Cosmetic Formulation in the Treatment of Skin Photoaging
المؤلفون المشاركون
Truchuelo, M. T.
Jiménez, N.
Miguel-Gomez, L.
Hermosa, A.
Sánchez-Neila, N.
Cuevas, J.
المصدر
Dermatology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Mechanism of action of cosmetic products is not often studied.
The aim of this study is to determine the histological, immunohistochemical, and clinical changes of a new cosmetic formulation.
Methods.
Prospective, single-blind, patient-controlled, randomized study in 10 volunteers with mild to moderate skin photoaging on the back of their hands.
The product was applied on one hand and a standard cream on the other hand, twice a day for three months.
Standardized photographs were taken on basal (T0) and final visit (T1) and skin biopsies were performed.
Changes on histological and immunohistochemical markers were studied.
Subjective clinical changes were determined.
Results.
After treatment, a 26.3% improvement on epidermal thickness was detected and a significant increase on collagens I and III, elastin, and fibronectin fibers was achieved (p<0.05).
As the expression of MMPs remained stable, this improvement of dermal matrix was attributed to the stimulation of their synthesis.
A significant clinical improvement on the treated hand was obtained, compared to control hand.
Conclusion.
This new cosmetic product with combination of three registered technologies (IFC-CAF, WGC, and RetinSphere), focused on regenerating dermal matrix and activating proliferation of skin cells, has shown to be efficient in the reversion of skin photoaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Truchuelo, M. T.& Jiménez, N.& Miguel-Gomez, L.& Hermosa, A.& Sánchez-Neila, N.& Cuevas, J.. 2017. Histological and Immunohistochemical Evaluation of the Efficacy of a New Cosmetic Formulation in the Treatment of Skin Photoaging. Dermatology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Truchuelo, M. T.…[et al.]. Histological and Immunohistochemical Evaluation of the Efficacy of a New Cosmetic Formulation in the Treatment of Skin Photoaging. Dermatology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Truchuelo, M. T.& Jiménez, N.& Miguel-Gomez, L.& Hermosa, A.& Sánchez-Neila, N.& Cuevas, J.. Histological and Immunohistochemical Evaluation of the Efficacy of a New Cosmetic Formulation in the Treatment of Skin Photoaging. Dermatology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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