p27-V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China
المؤلفون المشاركون
Zhang, Meng
Liang, Qianjun
Zhang, Ligang
Fan, Song
Liang, Chaozhao
Zhou, Jun
Hao, Zongyao
Zhang, Li
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
We conducted an update meta-analysis aiming to verify the association between p27-V109G polymorphism and cancer risk, particular for prostate cancer (PCa).
Then, we conducted a case-control study of Han Chinese in central China to verify the evidence-based results.
Methods.
Relevant studies were collected from diverse databases up to March 2017.
In addition, a hospital-based (H-B) case-control study enrolling 90 PCa patients and 140 healthy controls was included to verify these evidence-based findings.
Genetic risk was calculated by odds ratio (OR) with its corresponding 95% confidence interval (CI).
The p27-V109G polymorphism was determined by MassARRAY genotyping method.
Results.
Finally, twenty-four published studies comprising 9627 cases and 12,102 controls were enrolled for the current meta-analysis.
Overall analysis suggested that p27-V109G polymorphism decreased overall cancer risk in allelic contrast, heterozygote, and dominant models.
When stratified analysis was conducted by ethnicity, data revealed that p27-V109G polymorphism was associated with a decreased cancer risk in Caucasians.
Highlighted in the subgroup analysis by cancer type, we uncovered a significantly decreased risk of PCa in allelic contrast, dominant, homogeneous, and recessive models.
However, in the validation case-control study, we failed to uncover a positive association between p27-V109G polymorphism and PCa risk.
In addition, negative results were also identified when subgroup analyses were stratified by age, tumor grade, tumor stage, PSA levels, and other measurements.
Conclusion.
Although evidence-based results suggest that p27-V109G polymorphism plays a protective role in overall cancer risk, particularly for PCa, our case-control study failed to validate any association between this particular polymorphism and PCa risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Meng& Liang, Qianjun& Zhang, Ligang& Hao, Zongyao& Zhou, Jun& Zhang, Li…[et al.]. 2018. p27-V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Meng…[et al.]. p27-V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Meng& Liang, Qianjun& Zhang, Ligang& Hao, Zongyao& Zhou, Jun& Zhang, Li…[et al.]. p27-V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر