Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis
المؤلفون المشاركون
Wu, Huangan
Liu, Huirong
Zhao, Jimeng
Dong, Hongsheng
Huang, Yan
Li, Jing
Ma, Zhe
Dou, Chuanzi
Cui, Yunhua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
This study explored the mechanism of herb-partitioned moxibustion (HM) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) from the miRNA perspective.
Methods.
Rats were randomly divided into 3 groups [normal control (NC) group, UC model (UC) group, and herb-partitioned moxibustion (UCHM) group].
The UC and UCHM groups were administered 4% DSS for 7 days.
The UCHM group received HM at the Tianshu (bilateral, ST25).
The effect of HM on UC was observed and the miRNA expression profile in the colon tissues was analyzed.
Results.
Compared with the UC group, the body weights were significantly higher in the UCHM group on day 14 (P<0.001); the macroscopic colon injury scores and microscopic histopathology scores in the UCHM group decreased (P<0.05); and there were 15 differentially expressed miRNAs in the UCHM group.
The changes in miR-184 and miR-490-5p expression levels on the UC were reversed by HM intervention.
Validation using qRT-PCR showed that two miRNAs expression trend was consistent with the sequencing results.
Conclusion.
HM at ST25 might regulate miR-184 and miR-490-5p expression, act on the transcription of their target genes to regulate inflammatory signaling pathways, and attenuate inflammation and tissue injury in the colons of rats with DSS-induced UC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yan& Ma, Zhe& Cui, Yunhua& Dong, Hongsheng& Zhao, Jimeng& Dou, Chuanzi…[et al.]. 2017. Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153087
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yan…[et al.]. Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153087
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yan& Ma, Zhe& Cui, Yunhua& Dong, Hongsheng& Zhao, Jimeng& Dou, Chuanzi…[et al.]. Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153087
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153087
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر