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Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats
المؤلفون المشاركون
Kim, Seung-Hyung
Park, Bo-Kyung
Choi, Hye-Jin
Yang, Won-Kyung
Lee, Ji-Eun
Cho, Ju-Hyun
Park, In-Jae
Park, Sunyoung
Jin, Mirim
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We examined the antiosteoarthritic effect of the n-hexane extract of Litsea japonica fruit flesh (LJF-HE) in a rat model of monosodium-iodoacetate- (MIA-) induced osteoarthritis.
LJF-HE significantly reduced the difference in weight-bearing capabilities of the hind paws between healthy and MIA-treated rats.
Histological examination of the knee joints indicated that LJF-HE suppressed cartilage and bone destruction.
Additionally, there were decreases in the expression of matrix metalloproteinase-2 and metalloproteinase-9 and cyclooxygenase-2 in the joints.
The serum levels of deoxypyridinoline (DPD) and osteocalcin, which are markers of bone metabolism, also decreased.
Furthermore, LJF-HE significantly suppressed infiltration of inflammatory cells into the synovium and inhibited the expression of proinflammatory cytokines such as tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1, and IL-6 in the joints and serum.
The serum levels of leukotriene B4 and lipoxygenase were also significantly lowered by LJF-HE.
Finally, LJF-HE inhibited the production of nitric oxide, prostaglandin E2, IL-6, and TNF-α in lipopolysaccharide-activated macrophages, which might be associated with inhibited phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase.
Our data suggest that LJF-HE has an anti-inflammatory effect and may have potential as an antiosteoarthritic agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Seung-Hyung& Choi, Hye-Jin& Yang, Won-Kyung& Lee, Ji-Eun& Cho, Ju-Hyun& Park, In-Jae…[et al.]. 2017. Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153102
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Seung-Hyung…[et al.]. Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153102
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Seung-Hyung& Choi, Hye-Jin& Yang, Won-Kyung& Lee, Ji-Eun& Cho, Ju-Hyun& Park, In-Jae…[et al.]. Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153102
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153102
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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