Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS
المؤلفون المشاركون
Riezzo, Giuseppe
Russo, Francesco
Orlando, Antonella
Linsalata, Michele
D'Attoma, Benedetta
Clemente, Caterina
Chimienti, Guglielmina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Alterations of the small-intestinal permeability (s-IP) might play an essential role in a subgroup of diarrhoea-predominant IBS (D-IBS) patients.
Goals.
(a) To analyse in D-IBS patients the symptom profile in relation to the altered (+) or not (−) s-IP using the Gastrointestinal Symptom Rating Scale (GSRS).
(b) To assess the circulating levels of the adipokines IL-6, IL-8, TNF-α, leptin, and adiponectin, along with LPS, TLR-4, neurotensin, and brain-derived neurotrophic factor (BDNF).
The frequency distribution of SNPs at the loci for the investigated molecules and leptin receptor was evaluated.
Study.
The study included 34 D-IBS patients and 17 healthy controls (HC).
s-IP permeability was assayed by high-performance liquid chromatography determination in the urine of the lactulose to mannitol ratio.
Concentrations of IL-6, IL-8, TNF-α, LPS, TLR-4, leptin, adiponectin, neurotensin, and BDNF were assayed by ELISA.
Screening of genetic variants was done employing the restriction fragment length polymorphism-polymerase chain reaction method.
Results.
D-IBS(−) patients had a significantly higher GSRS cluster pain and diarrhoea profile than D-IBS(+) ones.
Significant correlations were found between the symptoms clusters and immune activation and inflammation markers.
The levels of adipo(cyto)kines in D-IBS(+) patients were higher than those of controls, and IL-6 levels correlated with those of LPS.
Leptin and BDNF were significantly higher, and neurotensin levels were significantly lower in D-IBS(+) than in controls.
No differences were found in the frequency distribution of genotypes among the study groups.
Conclusions.
Results from this study could be of some help in the characterization of the D-IBS and highlight the contribution of an altered intestinal barrier in the pathogenesis of this syndrome.
Besides, a role could be ascribed to molecules secreted by the visceral adipose tissue that can impact on barrier functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Russo, Francesco& Chimienti, Guglielmina& Riezzo, Giuseppe& Linsalata, Michele& D'Attoma, Benedetta& Clemente, Caterina…[et al.]. 2018. Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS. Disease Markers،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Russo, Francesco…[et al.]. Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS. Disease Markers No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1153106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Russo, Francesco& Chimienti, Guglielmina& Riezzo, Giuseppe& Linsalata, Michele& D'Attoma, Benedetta& Clemente, Caterina…[et al.]. Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر