Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment
المؤلفون المشاركون
Koch, Alexander
Roderburg, Christoph
Luedde, Mark
Vucur, Mihael
Loosen, Sven
Kaiser, Lukas
Schneider, Anne Theres
Roy, Sanchari
Luedde, Tom
Trautwein, Christian
Tacke, Frank
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Mixed lineage kinase domain-like (MLKL), a crucial regulator of necroptotic cell death, was shown to play a role in inflammatory diseases.
However, its role as a biomarker in critical illness and sepsis is currently unknown.
We analyzed serum levels of MLKL in 136 critically ill patients at admission to the intensive care unit (ICU) and after three days of ICU treatment.
Results were compared with 36 healthy controls and correlated with clinical and laboratory patients’ data.
MLKL serum levels of critically ill patients at admission to the ICU were similar compared to healthy controls.
At ICU admission, MLKL serum concentrations were independent of disease severity, presence of sepsis, and etiology of critical illness.
In contrast, median serum levels of MLKL after three days of ICU treatment were significantly lower compared to those at admission to the ICU.
While serum levels of MLKL at admission were not predictive for short-term survival during ICU treatment, elevated MLKL concentrations at day three were an independent negative predictor of patients’ ICU survival.
Thus, elevated MLKL levels after three days of ICU treatment were predictive for patients’ mortality, indicating that sustained deregulated cell death is associated with an adverse prognosis in critical illness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vucur, Mihael& Roderburg, Christoph& Kaiser, Lukas& Schneider, Anne Theres& Roy, Sanchari& Loosen, Sven…[et al.]. 2018. Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vucur, Mihael…[et al.]. Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vucur, Mihael& Roderburg, Christoph& Kaiser, Lukas& Schneider, Anne Theres& Roy, Sanchari& Loosen, Sven…[et al.]. Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر