Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease
المؤلفون المشاركون
Rizzo, Roberta
Greco, Antonio
Trentini, Alessandro
Bergamini, Carlo M.
Squerzanti, Monica
Zuliani, Giovanni
Passaro, Angelina
Sanz, Juana Maria
Bosi, Cristina
Cervellati, Carlo
Seripa, Davide
Giuseppe, Valacchi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Blood-based parameters reflecting systemic abnormalities associated with typical brain physiopathological hallmarks could be a satisfactory answer to the need of less costly/intrusive and widely available biomarkers for late onset Alzheimer’s disease (LOAD).
Cumulating evidence from ourselves and others suggests that systemic oxidative stress (OxS) is precociously associated with LOAD.
On this basis, we aimed to identify a combination of markers of redox status that could aid the diagnosis of LOAD.
Methods.
We reexamined and crossed previous data on 9 serum markers of OxS obtained in a cohort including n=84 controls and n=90 LOAD patients by multivariate logistic regression analyses.
Results.
A multimarker panel was identified that included significantly increased (hydroperoxides and uric acid) and decreased (thiols, residual antioxidant power, and arylesterase activity) markers.
The multivariate model yielded an area under receiver-operating characteristic curve (AUC) of 0.808 for the discrimination between controls and LOAD patients, with specificity and sensitivity of 64% and 79%, respectively.
Conclusions.
This study identified a panel of serum markers that distinguish individuals with LOAD from cognitively healthy control subjects.
Replication studies on a larger independent cohort are required to confirm and extend our data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zuliani, Giovanni& Passaro, Angelina& Bosi, Cristina& Sanz, Juana Maria& Trentini, Alessandro& Bergamini, Carlo M.…[et al.]. 2018. Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zuliani, Giovanni…[et al.]. Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zuliani, Giovanni& Passaro, Angelina& Bosi, Cristina& Sanz, Juana Maria& Trentini, Alessandro& Bergamini, Carlo M.…[et al.]. Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر