Clinical Impact and Prognostic Role of KRASBRAFPIK3CA Mutations in Stage I Colorectal Cancer
المؤلفون المشاركون
Maiorana, Antonino
Reggiani Bonetti, Luca
Bettelli, Stefania
Manfredini, Samantha
Caprera, Cecilia
Barresi, Valeria
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Stage I colorectal carcinoma has excellent prognosis, with 5-year survival rate up to 95%.
The occurrence of lymphovascular invasion, tumor budding, high number of PDC, or lymph node micrometastases is associated with tumor progression.
The aim of this study was to evaluate the mutational status of 62 stage I colorectal carcinomas (CRC) (taken from 37 patients surviving more than five years since the initial diagnosis and from 25 patients who died of disease) and to correlate it with histopathological features and the clinical outcome.
Mutations of KRAS, NRAS, BRAF, and PIK3CA genes were analyzed through Myriapod Colon Status Kit, using the high-throughput genotyping platform Sequenom MassARRAY System.
Mutations in those genes were found in 31 cases (50%) and mainly in those with poor prognosis.
The most frequent mutations occurred at codons 12 and 13 of the KRAS gene (40% of cases).
We found concomitant PIK3CA mutations in 5 cases (8%).
The presence of PIK3CA mutations was mainly observed in tumors with poor prognosis and with unfavorable histopathological prognostic features.
High PDC grade (P=0.0112), the presence of tumor budding (P=0.0334), LVI (P<0.0001), KRAS mutations (P=0.0228), PIK3CA mutations (P=0.0214), multiple genetic mutations in KRAS and PIK3CA genes (P=0.039), and nodal micrometastases (P<0.0001) were significant prognostic variables for CSS.
The presence of LVI was the only independent and statistically significant prognostic variable for CSS in our cohort of pTNM stage I CRCs.
The analysis of KRAS/PIK3CA mutational status may be used to identify patients with stage I CRC at high risk of bad outcome and who may need additional treatments, including biological therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reggiani Bonetti, Luca& Barresi, Valeria& Maiorana, Antonino& Manfredini, Samantha& Caprera, Cecilia& Bettelli, Stefania. 2018. Clinical Impact and Prognostic Role of KRASBRAFPIK3CA Mutations in Stage I Colorectal Cancer. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reggiani Bonetti, Luca…[et al.]. Clinical Impact and Prognostic Role of KRASBRAFPIK3CA Mutations in Stage I Colorectal Cancer. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reggiani Bonetti, Luca& Barresi, Valeria& Maiorana, Antonino& Manfredini, Samantha& Caprera, Cecilia& Bettelli, Stefania. Clinical Impact and Prognostic Role of KRASBRAFPIK3CA Mutations in Stage I Colorectal Cancer. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر