Total Flavonoids Extracted from Oxytropis falcata Bunge Improve Insulin Resistance through Regulation on the IKKβNF-κB Inflammatory Pathway
المؤلفون المشاركون
Yang, Lixia
Wang, Zhicheng
Jiang, Liangen
Sun, Wen
Fan, Qiang
Liu, Tonghua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Insulin resistance (IR) is the main etiology of type 2 diabetes mellitus (T2DM).
It has been known that total flavonoid extracts can markedly improve the hypoglycemic symptoms caused by IR.
Nevertheless, the relevant molecular mechanism remains unclarified.
Aim.
This study aimed to investigate the antihyperglycemic effects and mechanism of the total flavonoid extract from Oxytropis falcata Bunge.
Methods.
STZ-induced T2DM rats (n=35) were divided into 5 groups: model, low-, medium-, and high-dose total flavonoids, and pioglitazone groups.
Ten healthy rats were used as controls.
The serum insulin and inflammatory cytokines (MCP-1, TNF-α, and IL-6) level was measured by ELISA.
The concentration of IRS-1, p-IRS-1, PKB p-PKB, PI3Kp85, and p-PI3K in skeletal muscles was determined by Western blot.
The mRNA level of GLUT4, IκB, and NF-κB in skeletal muscle was detected by qRT-PCR.
Results.
The treatment of medium- and high-dose total flavonoids significantly reduced the FPG and P2hPG and enhanced insulin level in T2DM rats (P<0.05).
When compared with controls, the serum level of MCP-1, TNF-α, IL-6, IRS-1, and p-IRS-1 was significantly increased in T2DM rats, but the level of PKB, p-PKB, PI3Kp85, and p-PI3K expression was reduced (P<0.05).
The GLUT4 and IκB mRNA expression were significantly decreased, and NF-κB mRNA level was increased (P<0.05).
The treatment of low-, medium-, or high-dose total flavonoids markedly reversed the changes above (P<0.05).
Conclusion.
Our study has confirmed the therapeutic effects of total flavonoids from Oxytropis falcata Bunge on IR.
The flavonoids might reduce the production of inflammatory cytokines through downregulation of NF-κB expression in inflammatory pathway and regulate the IRS-1-PI3-K-PKB/Akt insulin pathway and thereby increased the GLUT4 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Lixia& Wang, Zhicheng& Jiang, Liangen& Sun, Wen& Fan, Qiang& Liu, Tonghua. 2017. Total Flavonoids Extracted from Oxytropis falcata Bunge Improve Insulin Resistance through Regulation on the IKKβNF-κB Inflammatory Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Lixia…[et al.]. Total Flavonoids Extracted from Oxytropis falcata Bunge Improve Insulin Resistance through Regulation on the IKKβNF-κB Inflammatory Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1153247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Lixia& Wang, Zhicheng& Jiang, Liangen& Sun, Wen& Fan, Qiang& Liu, Tonghua. Total Flavonoids Extracted from Oxytropis falcata Bunge Improve Insulin Resistance through Regulation on the IKKβNF-κB Inflammatory Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر