![](/images/graphics-bg.png)
Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study
المؤلفون المشاركون
Milewski, Robert
Konarzewska, Beata
Szulc, Agata
Tarasów, Eugeniusz
Waszkiewicz, Napoleon
Galińska-Skok, Beata
Małus, Aleksandra
Rogowska-Zach, Anna
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Modern neuroimaging techniques allow investigating brain structures and substances involved in the pathophysiology of mental disorders, trying to find new markers of these disorders.
To better understanding of the pathophysiology and differential diagnosis of schizophrenia and bipolar disorder, this study was conducted to assess the neurochemical alterations in the frontal and temporal lobes in hospitalized patients with schizophrenia and bipolar disorder.
Methods.
Twenty-one subjects with schizophrenia (paranoid and differentiated types), 16 subjects with bipolar I disorder (manic, depressive, and mixed episode), and 20 healthy subjects were studied.
Magnetic resonance (MR) imaging and proton resonance magnetic spectroscopy (1H MRS) were performed on a 1.5 T scanner.
Voxels of 8 cm3 were positioned in the left frontal and left temporal lobes.
Results.
Glx/H2O (GABA, glutamine, and glutamate/nonsuppressed water signal) ratios were significantly increased in the left temporal lobe in schizophrenia, but not in bipolar disorder, compared with controls.
Cho/H2O (choline/nonsuppressed water signal) ratios in the left frontal lobe had a tendency to increase in bipolar disorder and schizophrenia, relative to controls.
A lower temporal lobe NAA/H2O ratio in mixed than in manic and depressive episode of bipolar patients was also found.
No other significant differences were found among three studied groups as regards NAA, Cr, and mI ratios.
Conclusions.
Our results partially confirm the role of a glutamatergic system in schizophrenia, however, only in a temporal lobe.
We also point to the importance of the choline-containing compounds (marker of cellular density) in the frontal lobe of patients suffering from bipolar disorder and schizophrenia.
We also found the deleterious effect of mixed bipolar episode on the integrity and functioning of the temporal lobe.
Glutamatergic left temporal spectroscopic changes may potentially help in differential diagnosis of schizophrenia from bipolar disorder.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Galińska-Skok, Beata& Małus, Aleksandra& Konarzewska, Beata& Rogowska-Zach, Anna& Milewski, Robert& Tarasów, Eugeniusz…[et al.]. 2018. Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Galińska-Skok, Beata…[et al.]. Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Galińska-Skok, Beata& Małus, Aleksandra& Konarzewska, Beata& Rogowska-Zach, Anna& Milewski, Robert& Tarasów, Eugeniusz…[et al.]. Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)