Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3KAKTmTOR Pathway
المؤلفون المشاركون
Wu, Jiliang
Yu, Wei
Zha, Wenliang
Sun, Huirong
Xu, Ling
Min, Qing
Cui, Weili
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Treatment with Adriamycin (ADR) is one of the major causes of chemotherapy-induced cardiotoxicity and therefore is the principal limiting factor in the effectiveness of chemotherapy for cancer patients.
Apigenin (API) has been shown to play a cardioprotective role.
The present study examined the effect of API on ADR-induced cardiotoxicity in mice.
Sixty male Kunming mice were randomly divided into 4 groups: a control group, ADR model group, low-dose API treatment group (125 mg·kg−1), and high-dose API treatment group (250 mg·kg−1).
Blood samples were taken to evaluate a spectrum of myocardial enzymes.
Cardiomyocyte apoptosis was measured using a TUNEL assay, and cardiomyocyte autophagy was observed using electron microscopy.
Moreover, apoptosis-related proteins, such as Bax and Bcl-2, autophagy-related proteins, including Beclin1 and LC3B, and PI3K/AKT/mTOR pathway-related proteins were examined with western blot.
Our results demonstrate that ADR caused an increase in the serum levels of cardiac injury markers and enhanced cardiomyocyte apoptosis and autophagy.
API administration prevented the effects associated with ADR-induced cardiotoxicity in mice and inhibited ADR-induced apoptosis and autophagy.
API also promoted PI3K/AKT/mTOR pathway activity in ADR-treated mice.
In conclusion, API may have a protective effect against ADR-induced cardiotoxicity by inhibiting apoptosis and autophagy via activation of the PI3K/AKT/mTOR pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Wei& Sun, Huirong& Zha, Wenliang& Cui, Weili& Xu, Ling& Min, Qing…[et al.]. 2017. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3KAKTmTOR Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Wei…[et al.]. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3KAKTmTOR Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Wei& Sun, Huirong& Zha, Wenliang& Cui, Weili& Xu, Ling& Min, Qing…[et al.]. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3KAKTmTOR Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر