Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats
المؤلفون المشاركون
Jichao, Sun
Xinmin, Han
Xianguo, Ren
Dongqi, Yin
Rongyi, Zhou
Shuang, Lei
Yue, You
Yuchen, Song
Jingnan, Ying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF) expression are due in part to be associated with attention deficit hyperactivity disorder (ADHD).
In this study, we investigated the therapeutical effect of saikosaponin a (SSa) isolated from Bupleurum Chinese DC, against spontaneously hypertensive rat (SHR) model of ADHD.
Methylphenidate and SSa were orally administered for 3 weeks.
Activity was assessed by open-field test and Morris water maze test.
Dopamine (DA) and BDNF were determined in specific brain regions.
The mRNA or protein expression of tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicles monoamine transporter (VMAT) was also studied.
Both MPH and SSa reduced hyperactivity and improved the spatial learning memory deficit in SHRs.
An increased DA concentration in the prefrontal cortex (PFC) and striatum was also observed after treating with the SSa.
The increased DA concentration may partially be attributed to the decreased mRNA and protein expression of DAT in PFC while SSa exhibited no significant effects on the mRNA expression of TH and VMAT in PFC of SHRs.
In addition, BDNF expression in SHRs was also increased after treating with SSa or MPH.
The obtained result suggested that SSa may be a potential drug for treating ADHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jichao, Sun& Xinmin, Han& Xianguo, Ren& Dongqi, Yin& Rongyi, Zhou& Shuang, Lei…[et al.]. 2017. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jichao, Sun…[et al.]. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jichao, Sun& Xinmin, Han& Xianguo, Ren& Dongqi, Yin& Rongyi, Zhou& Shuang, Lei…[et al.]. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر