Gastrodia elata Blume Rhizome Aqueous Extract Improves Arterial Thrombosis, Dyslipidemia, and Insulin Response in Testosterone-Deficient Rats
المؤلفون المشاركون
Kim, Min Jung
Yang, Hye Jeong
Moon, Bo Reum
Kim, Ji Eun
Kim, Kang Sung
Park, Sunmin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Testosterone deficiency deteriorates glucose and lipid metabolism with reducing muscle mass.
We investigated whether the consumption of water extracts of Gastrodia elata Blume rhizome (GEB) rich in gastrodin would reduce the symptoms of testosterone deficiency and improve blood flow in orchidectomized (ORX) rats.
ORX rats were given high-fat diets supplemented with either 1% cellulose (ORX-control), 0.3% GEB (GEB-L), or 1% GEB (GEB-H) for 8 weeks.
Sham-operated rats were fed the same diet as OVX-control rats (normal-control).
ORX-control rats had reduced serum testosterone levels by one-fifth, compared to normal-control rats.
ORX-control rats exhibited decreased lean body mass, attenuated blood flow, and impaired cholesterol metabolism and glucose control due to decreased insulin secretory response.
GEB increased serum insulin levels dose-dependently and GEB-H mostly enhanced dyslipidemia in ORX rats.
GEB completely normalized arterial thrombosis time and blood flow in ORX rats.
Interestingly, ORX-control rats showed attenuated hepatic insulin signaling but greater AMPK and CREB activities, which reduced triglyceride accumulation, compared to normal-control.
GEB-H improved hepatic insulin signaling but maintained the AMPK and CREB activities in ORX rats.
In conclusions, GEB ameliorated the impairment of cholesterol and glucose metabolism and blood flow in ORX rats.
GEB may be a potential preventive measure for reducing the risk of cardiovascular diseases associated with testosterone deficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Min Jung& Yang, Hye Jeong& Moon, Bo Reum& Kim, Ji Eun& Kim, Kang Sung& Park, Sunmin. 2017. Gastrodia elata Blume Rhizome Aqueous Extract Improves Arterial Thrombosis, Dyslipidemia, and Insulin Response in Testosterone-Deficient Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Min Jung…[et al.]. Gastrodia elata Blume Rhizome Aqueous Extract Improves Arterial Thrombosis, Dyslipidemia, and Insulin Response in Testosterone-Deficient Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Min Jung& Yang, Hye Jeong& Moon, Bo Reum& Kim, Ji Eun& Kim, Kang Sung& Park, Sunmin. Gastrodia elata Blume Rhizome Aqueous Extract Improves Arterial Thrombosis, Dyslipidemia, and Insulin Response in Testosterone-Deficient Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر