Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population
المؤلفون المشاركون
Vishweswaraiah, Sangeetha
Thimraj, Tania Ahalya
George, Leema
Krishnarao, Chaya Sindaghatta
Lokesh, Komarla Sundararaja
Siddaiah, Jayaraj Biligere
Larsson, Kjell
Upadhyay, Swapna
Palmberg, Lena
Ganguly, Koustav
Padukudru Anand, Mahesh
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Rationale.
Exposure to biomass smoke (BMS) has been implicated in chronic obstructive pulmonary disease (COPD).
About 3 billion people worldwide use biomass fuel for cooking and heating.
Women in rural communities of low- and lower-middle-income countries are disproportionately exposed to massive amounts of BMS during active cooking hours (4–6 h/day).
Therefore, BMS exposure is considered as a risk factor for COPD in the same order of magnitude as tobacco smoke.
In rural India, due to cultural reasons, women are the primary cook of the family and are mostly nonsmokers.
Thus, BMS-induced COPD is predominant among rural Indian women.
However, BMS-COPD remains a relatively unexplored health problem globally.
Therefore, we investigated the serum chemokine and cytokine signatures of BMS-COPD and tobacco smoke-induced COPD (TS-COPD) patients compared to their control in a rural South Indian population for this field study.
Methods.
Concentrations of 40 serum chemokines and cytokines were measured using a multiplexed immunoassay.
The study cohort consisted of BMS-COPD (female; n=29) and BMS-exposed subjects without COPD (BMS-CONTROL; female; n=24).
For comparison, data from TS-COPD patients (male, n=23) and tobacco smokers without COPD (TS-CONTROL; male, n=22) were investigated.
Subjects were matched for age, sex, and biomass exposure.
Tobacco consumption was slightly higher in TS-COPD subjects compared to TS-CONTROL.
BMS-exposed and TS-exposed subjects (currently exposed) were from the same locality with similar dwelling habits and socioeconomic status.
A validated structured questionnaire-based survey and spirometry was performed.
An additional control group with no tobacco and BMS exposure (TS-BMS-CONTROL; n=15) was included.
Statistical significance was set at p≤0.01.
Results.
Serum median concentrations (pg/ml) of CCL15 [8799.35; 5977.22], CCL27 [1409.14; 1024.99], and CXCL13 [37.14; 26.03] were significantly higher in BMS-CONTROL compared to BMS-COPD subjects.
Nine analytes exhibited higher concentrations in TS-CONTROL compared to TS-COPD subjects.
Comparison of chemokine and cytokine concentrations among BMS-COPD versus TS-COPD and BMS-CONTROL versus TS-CONTROL subjects also revealed distinct molecular signatures.
Conclusion.
Our data identifies CCL27 and CXCL13 as putative, plausibly homeostatic/protective biomarkers for BMS-COPD within the investigated population that warrants validation in larger and multiple cohorts.
The findings further indicate exposure-specific systemic response of chemokines and cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vishweswaraiah, Sangeetha& Thimraj, Tania Ahalya& George, Leema& Krishnarao, Chaya Sindaghatta& Lokesh, Komarla Sundararaja& Siddaiah, Jayaraj Biligere…[et al.]. 2018. Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153378
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vishweswaraiah, Sangeetha…[et al.]. Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153378
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vishweswaraiah, Sangeetha& Thimraj, Tania Ahalya& George, Leema& Krishnarao, Chaya Sindaghatta& Lokesh, Komarla Sundararaja& Siddaiah, Jayaraj Biligere…[et al.]. Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153378
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153378
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر