A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder
المؤلفون المشاركون
Inamoto, Teruo
Uehara, Hirofumi
Akao, Yukihiro
Ibuki, Naokazu
Komura, Kazumasa
Takahara, Kiyoshi
Takai, Tomoaki
Uchimoto, Taizo
Saito, Kenkichi
Tanda, Naoki
Yoshikawa, Yuki
Minami, Koichiro
Hirano, Hajime
Nomi, Hayahito
Kato, Ryuji
Hayashi, Tetsuya
Azuma, Haruhito
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction and Objectives.
MicroRNA (miRNA) expression is altered in urologic malignancies, including urothelial carcinoma of the bladder (UCB).
Individual miRNAs have been shown to modulate multiple signaling pathways that contribute to BC.
To identify a panel of miRNA signature that can predict aggressive phenotype from normal nonaggressive counterpart using miRNA expression levels and to assess the prognostic value of this specific miRNA markers in patients with UCB.
Methods.
To determine candidate miRNAs as prognostic biomarkers for dividing aggressive type of UCB, miRNA expression was profiled in patients’ samples with an aggressive phenotype or nonaggressive phenotype using 3D-Gene miRNA labeling kit (Toray, Japan).
To create a prognostic index model, we used the panel of 9-miRNA signature based on Cancer Genome Atlas (TCGA) data portal (TCGA Data Portal (https://tcgadata.nci.nih.gov/tcga/tcgaHome2.jsp)).
miRNA expression data and corresponding clinical data, including outcome and staging information of 84 UCB patients, were obtained.
The Kaplan-Meier and log-rank test were performed to quantify the survival functions in two groups.
Results.
Deregulation of nine miRNAs (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-145-5p, hsa-miR-4324, hsa-miR-34b-5p, hsa-miR-29c-3p, hsa-miR-135a-3p, and hsa-miR-33b-3p) was determined in UCB patients with aggressive phenotype compared with nonaggressive subject.
To validate the prognostic power of the nine-signature miRNAs using the TCGA dataset of bladder cancer, the survival status and tumor miRNA expression of all 84 TCGA UCB patients were ranked according to the prognostic score values.
Of nine miRNAs, six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p).
Patients with the high-risk miRNA signature exhibited poorer OS than patients expressing the low-risk miRNA profile (HR = 7.05, p<0.001).
Conclusions.
The miRNA array identified nine dysregulated miRNAs from clinical samples.
This panel of nine-miRNA signature provides predictive and prognostic value of patients with UCB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Inamoto, Teruo& Uehara, Hirofumi& Akao, Yukihiro& Ibuki, Naokazu& Komura, Kazumasa& Takahara, Kiyoshi…[et al.]. 2018. A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Inamoto, Teruo…[et al.]. A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Inamoto, Teruo& Uehara, Hirofumi& Akao, Yukihiro& Ibuki, Naokazu& Komura, Kazumasa& Takahara, Kiyoshi…[et al.]. A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر