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Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice
المؤلفون المشاركون
Li, Zhigang
Jiang, Jing
Ding, Ning
Lu, Menghan
Hu, Jiatong
Xu, Yiyuan
Liu, Xiaoxiao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect of manual acupuncture (MA) on NLRP3 inflammasome-related proteins.
Methods.
SAMP8 mice were randomly divided into Alzheimer’s disease (AD) group, the MA group, and the medicine (M) group.
Mice in the M group were treated with donepezil hydrochloride at 0.65 μg/g.
In the MA group, MA was applied on Baihui (GV20) and Yintang (GV29) for 20 min and then pricked at Shuigou (GV26).
The Morris water maze was applied to assess spatial learning and memory.
Immunohistochemical staining and western blot analysis were used to observe the expression of NLRP3 inflammasome-related proteins.
Results.
Compared with the normal (N) control group, spatial learning and the memory capabilities of the AD group significantly decreased (p<0.01).
The number of NLRP3, ASC, Caspase-1, and IL-1β positively stained cells in the AD group was higher than the N group, and the relative expression levels of the above proteins were significantly higher than those in the N group (p<0.01).
These changes were reversed by both MA and donepezil (p<0.01).
Conclusion.
MA can improve the learning and memory capabilities of SAMP8 mice.
The negative regulation of the NLRP3/Caspase-1 pathway in the hippocampus may be a possible mechanism of MA in the treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Ning& Jiang, Jing& Lu, Menghan& Hu, Jiatong& Xu, Yiyuan& Liu, Xiaoxiao…[et al.]. 2017. Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Ning…[et al.]. Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Ning& Jiang, Jing& Lu, Menghan& Hu, Jiatong& Xu, Yiyuan& Liu, Xiaoxiao…[et al.]. Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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