Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy
المؤلفون المشاركون
Wang, Liang
Chen, Menglong
Xu, Min
Li, Jing
Feng, Pinning
He, Ruojie
Zhu, Yuling
Li, Huan
Lin, Jinfu
Zhang, Cheng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the ratios of creatine kinase (CK) to aminotransferases as biomarkers of acute liver injury in dystrophinopathy.
Methods.
C57 and mdx (dystrophic) mice were treated with a hepatotoxic reagent D-galactosamine (D-GalN).
The degrees of liver and muscle injury were assessed using histological examinations.
To examine whether serum CK-adjusted aminotransferase levels could indicate liver status in dystrophic mice, the CK/alanine aminotransferase (ALT) and CK/aspartate aminotransferase (AST) ratios were analyzed.
Furthermore, we enrolled 658 male patients with dystrophinopathy and 378 male patients without muscle and liver injury as control, whose serum ALT, AST, and CK levels were examined.
Results.
Animal experiments indicated that D-GalN treatment could induce acute liver injury but not muscle injury.
Additionally, D-GalN decreased the CK/ALT and CK/AST ratios in both C57 mice and mdx mice (P<0.001).
However, there was an overlap of the CK/AST ratio between dystrophic mice with and without acute liver injury.
In patients with dystrophinopathy, CK-adjusted ALT diminished the variability associated with age, genotype, clinical phenotype, and motor function (P>0.05).
Conclusions.
CK/ALT is a potential biomarker for the differential evaluation of acute liver injury in dystrophic mice, which highlights the value to further evaluate the practice of CK/ALT in dystrophinopathy patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liang& Chen, Menglong& Xu, Min& Li, Jing& Feng, Pinning& He, Ruojie…[et al.]. 2018. Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153513
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liang…[et al.]. Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153513
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liang& Chen, Menglong& Xu, Min& Li, Jing& Feng, Pinning& He, Ruojie…[et al.]. Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153513
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153513
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر