Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PETCT Scan with Tissue Biomarkers
المؤلفون المشاركون
Foca, Flavia
Martinelli, Giovanni
Liverani, Chiara
Bongiovanni, Alberto
Mercatali, Laura
Pieri, Federica
De Vita, Alessandro
Spadazzi, Chiara
Miserocchi, Giacomo
Recine, Federica
Riva, Nada
Nicolini, Silvia
Severi, Stefano
Ibrahim, Toni
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is a growing need for more accurate biomarkers to facilitate the diagnosis and prognosis of patients with grade (G) 3 neuroendocrine carcinomas (NECs).
In particular, the discrimination between well-differentiated neuroendocrine carcinomas (WD-NECs) and poorly differentiated neuroendocrine carcinomas (PD-NECs) is still an unmet need.
We previously showed that 68Gallium-(68Ga-) PET/CT positivity is a prognostic factor in patients with gastroenteropancreatic (GEP) G3 NECs, correlating with a better outcome in terms of overall survival.
Here, we hypothesize that 68Ga-PET/CT could help to discriminate between WD-NECs and PD-NECs, adding complementary information to that obtained from morphologic and biologic factors.
A retrospective, single-institution study was performed on 11 patients with histologically confirmed, measurable G3 large- or small-cell GEP-NECs according to the 2017 WHO classification.
The staging procedures included a 68Ga-PET/CT scan.
Results of 68Ga-PET/CT were correlated in univariate analysis with loss of tissue immunohistochemical expression of DAXX/ATRX or RB1 frequently associated with WD-NECs or PD-NECs, respectively.
None of the patients with positive 68Ga-PET/CT showed loss of RB1 expression, whereas among those (n=6) with negative 68Ga-PET/CT, 4 showed loss of expression.
A trend towards a correlation between loss of RB1 expression and negative 68Ga-PET/CT was observed.
Our preliminary data support the hypothesis that PD-NECs carrying RB1 mutation and loss of its expression may be associated with negative 68Ga-PET/CT.
If confirmed in a larger clinical trial, 68Ga-PET/CT would help in the stratification of G3 NECs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liverani, Chiara& Bongiovanni, Alberto& Mercatali, Laura& Foca, Flavia& Pieri, Federica& De Vita, Alessandro…[et al.]. 2018. Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PETCT Scan with Tissue Biomarkers. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liverani, Chiara…[et al.]. Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PETCT Scan with Tissue Biomarkers. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liverani, Chiara& Bongiovanni, Alberto& Mercatali, Laura& Foca, Flavia& Pieri, Federica& De Vita, Alessandro…[et al.]. Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PETCT Scan with Tissue Biomarkers. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر