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Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Sun, Shuai
Li, Bowen
Li, Xiang
Wang, Feng
Yang, Hongyu
Shen, Yuehong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck region.
The circular RNA (circRNA) is known to serve an important role in the carcinogenesis of different types of cancer.
However, the circRNA role of OSCC remains unclear.
Methods.
8 pairs of OSCC tissues and adjacent normal tissues were obtained to detect circRNAs expression by high-throughput sequencing, and 45 pairs of OSCC tissues were selected to verify the differentially significant circRNAs by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
To further investigate the role of hsa_circ_0008309, the circRNA-microRNA (miR)-mRNA network was predicted using bioinformatics databases.
The expression levels of hsa_circ_0008309, miR-1290, miR-136-5P, and miR-382-5P in SCC-15 and CAL27 cell lines were detected by RT-qPCR.
Western blotting was performed to detect the protein level of Ataxin 1 (ATXN1).
Results.
The high-throughput sequencing results demonstrated that circRNAs were abundantly expressed in OSCC, and 16 circRNAs were significantly differentially expressed.
Hsa_circ_0008309 was significantly downregulated in 45 pairs of OSCC tissue samples and was statistically correlated with pathological differentiation.
The bioinformatics databases suggested that hsa_circ_0008309 could combine with miR-1290, miR-136-5P, and miR-382-5P, respectively, to regulate the expression of ATXN1.
It was subsequently identified that hsa_circ_0008309 may inhibit miR-136-5P and miR-382-5P expression and increase ATXN1 expression in the OSCC cell lines.
Conclusion.
In summary, the results of the present study revealed that OSCC tissues have abundant circRNAs and, to the best of our knowledge, we firstly explore the regulatory role of the hsa_circ_0008309-miR-136-5P/hsa-miR-382-5P-ATXN1 network in OSCC.
The results indicated that hsa_circ_0008309 may be a potential biomarker for OSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Bowen& Wang, Feng& Li, Xiang& Sun, Shuai& Shen, Yuehong& Yang, Hongyu. 2018. Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153652
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Bowen…[et al.]. Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153652
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Bowen& Wang, Feng& Li, Xiang& Sun, Shuai& Shen, Yuehong& Yang, Hongyu. Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153652
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153652
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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