Buyang Huanwu Decoction Ameliorates Poststroke Depression via Promoting Neurotrophic Pathway Mediated Neuroprotection and Neurogenesis
المؤلفون المشاركون
Luo, Lin
Deng, Shuhua
Yi, Jian
Zhou, Sainan
She, Yan
Liu, Baiyan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The aim of the present research is to investigate the therapeutic effect of Buyang Huanwu Decoction (BHD) in poststroke depression (PSD) animal model and illustrate its underlying mechanism via promoting neurotrophic pathway mediated neuroprotection and neurogenesis.
Methods.
To induce PSD rat model, isolation housed rats that received middle cerebral artery occlusion (MCAO) surgery successively suffered from chronic mild stress (CMS) treatment for consecutive twenty-one days.
Meanwhile, rats were correspondingly given vehicle, BHD, and fluoxetine.
Then, neurologic function was scored and depressive-like behaviors were assessed by sucrose preference test, locomotor activity, novelty-suppressed feeding test, and forced swim test.
Thereafter, the neuroprotection and neurogenesis related molecular markers and signaling were detected.
Results.
We firstly observed a significant neurological function recovery and antidepressants effect of BHD after MCAO together with CMS treatment.
Our study also found that treatment with BHD and fluoxetine can significantly rescue neurons from apoptosis and promote neurogenesis in the CA3 and DG regions in the hippocampus.
Notably, BHD and fluoxetine treatment can activate BDNF/ERK/CREB signaling.
Conclusion.
The results suggest that BHD is a promising candidate for treating PSD.
Its curative effects can be attributed to neurotrophic pathway mediated neuroprotection and neurogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Lin& Deng, Shuhua& Yi, Jian& Zhou, Sainan& She, Yan& Liu, Baiyan. 2017. Buyang Huanwu Decoction Ameliorates Poststroke Depression via Promoting Neurotrophic Pathway Mediated Neuroprotection and Neurogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Lin…[et al.]. Buyang Huanwu Decoction Ameliorates Poststroke Depression via Promoting Neurotrophic Pathway Mediated Neuroprotection and Neurogenesis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Lin& Deng, Shuhua& Yi, Jian& Zhou, Sainan& She, Yan& Liu, Baiyan. Buyang Huanwu Decoction Ameliorates Poststroke Depression via Promoting Neurotrophic Pathway Mediated Neuroprotection and Neurogenesis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر